HOME >> MEDICINE >> NEWS
Draining away brain's toxic protein to stop Alzheimer's

Scientists are trying a plumbers approach to rid the brain of the amyloid buildup that plagues Alzheimers patients: Simply drain the toxic protein away.

Thats the method outlined in a paper published online August 12 by Nature Medicine. Scientists from the University of Rochester Medical Center show how the bodys natural way of ridding the body of the substance is flawed in people with the disease. Then the team demonstrated an experimental method in mice to fix the process, dramatically reducing the levels of the toxic protein in the brain and halting symptoms. The team is now working on developing a version of the protein that could be tested in people with the disease.

The approach doesnt take direct aim at the pathology that is ubiquitous in the Alzheimers patients brains, where amyloid-beta forms a toxic plaque. Instead, researchers take an indirect approach, focusing not on the brain but rather on a protein that sops up amyloid-beta in the body, where its regarded as harmless. The scientists found that if they increase the bodys ability to soak up amyloid, the brain responds, causing levels of the substance in the brain the real target to plummet.

There is a dynamic equilibrium between the levels of amyloid-beta in the blood and in the brain, said neuroscientist Berislav Zlokovic, M.D., Ph.D., the leader of the team. If we are able to lower the levels of amyloid-beta circulating in blood by sequestering more of it there, then the brain should follow and lower its levels too. This is exactly what we found.

The team concentrated its efforts around a protein known as sLRP (soluble low-density lipoprotein receptor-related protein). The team discovered that in healthy people, the protein binds to and neutralizes anywhere from 70 to 90 percent of the amyloid-beta that is circulating in the body.

The team also found that sLRP is doing only a fraction of the job in Alzheimers patients that it does in healthy peopl
'"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
12-Aug-2007


Page: 1 2 3

Related medicine news :

1. Emotional control circuit of brains fear response discovered
2. Transcendental Meditation reduces the brains reaction to pain
3. Multi-tasking adversely affects brains learning, UCLA psychologists report
4. Studies of married couples, soccer and hockey teams focus on brains response to stress
5. Flick of whiskers helps tease out brains shadow signaling system
6. The brains motivation station
7. Oops! Researchers publish new findings on the brains response to costly mistakes
8. Animal models show that anabolic steroids flip the adolescent brains switch for aggression
9. New antidepressant drug increases brains own cannabis
10. Hopkins study proves cochlear implants prevent or reverse damage to brains auditory nerve system
11. Shift in brains language-control site offers rehab hope

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD ... dose required and providing a CBD form that can be easily incorporated into liquid ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology:
Cached News: