HOME >> MEDICINE >> NEWS
Drug aimed at Huntington's eases chorea, the disease's hallmark feature

A drug widely available in Europe and Canada but not the United States dramatically eases one of the most disabling symptoms of Huntingtons disease, involuntary writhing movements known as chorea, according to a study in the Feb. 14 issue of the journal Neurology.

The medication, tetrabenazine, is currently being reviewed by the U.S. Food and Drug Administration. If approved, the medication would be the first authorized by the agency expressly for the treatment of Huntingtons disease, which affects about 30,000 people in the United States.

In a randomized, controlled study conducted in 84 patients at 16 sites around the nation, doctors found that the medication cut down involuntary movement on average by about 25 percent, with many patients experiencing a greater improvement. Overall, patients who received the medication were six times as likely to be considered by their doctors to have improved considerably, compared to participants who received a placebo.

Neuroleptic drugs like haloperidol (Haldol) are currently in widespread use in the United States to suppress chorea, but the effect of these drugs on chorea has never been studied in a systematic way, and they have a number of troublesome side effects, such as blunting of personality, loss of voluntary movement, and hindering balance. Our study showed that tetrabenazine, when appropriately dosed, can decrease chorea without causing those side effects, said Frederick J. Marshall, M.D., a neurologist at the University of Rochester Medical Center who led the study conducted by the Huntington Study Group. The study was funded by Prestwick Pharmaceuticals of Washington, D.C., the company that owns the rights to develop and sell the medication in the United States.

Tetrabenazine was originally developed in the 1950s to treat psychosis, but was quickly pushed aside by more effective medications. But doctors in the United Kingdom found it to be effective to treat the excessive involuntar
'"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
13-Feb-2006


Page: 1 2 3 4

Related medicine news :

1. Science of healthy foods subject of grant aimed at university students
2. Drug ads aimed at cancer patients difficult to read, make more appeals to effectiveness than safety
3. Cardiovascular flow disturbances study aimed at improving diagnosis and treatment
4. Endocrinologist-directed intervention aimed at primary care physicians improves diabetes care
5. New technology to speed up research into Huntingtons disease
6. Study identifies possible mechanism for brain damage in Huntingtons disease
7. Study identifies potential drug target for Huntingtons disease
8. Neural transplants provide persistent benefit in patients with Huntingtons disease
9. Rush designated Center of Excellence by Huntingtons Disease Society of America
10. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
11. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Drug aimed Huntington eases chorea the disease hallmark feature

(Date:3/31/2015)... CA (PRWEB) March 31, 2015 Over ... robotic hair transplant technique have yielded better results ... , when refined and perfected by a good hair ... the most advanced techniques of hair restoration have improved ... can still be used to add precision and flexibility ...
(Date:3/31/2015)... In conjunction with the Asbestos ... the Mesothelioma Applied Research Foundation (Meso Foundation) announced ... complement its existing work in mesothelioma research, education, ... the Meso Foundation’s mission, we want to eliminate ... to asbestos, including mesothelioma,” said the Meso Foundation’s ...
(Date:3/31/2015)... Nashua, NH (PRWEB) March 31, 2015 ... Class of 2015 at Rivier University’s Commencement ... honorary doctorate of humane letters in recognition of her ... educator. , Serving as a front-line caregiver and senior ... for 25 years and advancing to leadership roles, including ...
(Date:3/31/2015)... Many people, including the ones with physical challenges, ... are only for able-bodied participants. , A new ... to change that thinking. , The program, part ... Sports Expo on Saturday, April 11 (10 a.m. to ... , The event will showcase a wide variety ...
(Date:3/31/2015)... 2015 OnChip Devices , a world ... silicon ESD diode chip targeted towards low voltage LED applications. ... Zeners are ideal for protecting circuits by suppressing voltage higher ... handle pulses of up to 350W and 20A, providing protection ... 61000-4-2 standard. These diodes do not exhibit any device ...
Breaking Medicine News(10 mins):Health News:Beverly Hills Hair Transplant Surgeon Now Combines Advanced Robotic Hair Transplantation and Manual Techniques for Greatest Results 2Health News:Mesothelioma Research Organization Announces New Prevention Program 2Health News:Mesothelioma Research Organization Announces New Prevention Program 3Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 2Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 3Health News:Memorial Healthcare System's Adaptive Sports Expo Encourages Physically Challenged To Go Beyond Perceived Limitations 2Health News:OnChip Introduces Low Voltage Diodes for High-Brightness LED Protection 2
(Date:3/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/5r9f3t/eurpoean ... "Eurpoean Automatic External Defibrillators (AED) Market by Product ... Hospitals, Alternate Care Market, Home) - Forecast to ... The European automated external defibrillator (AED) market is ... from 2014 to 2019 ...
(Date:3/31/2015)... , March 31, 2015  The efficacy of continuous ... in a recently published study 1 of ultraviolet ... research team, including Curtis Donskey , M.D.  The ... for the same length of time from the same ... unit.  The results showed surprisingly low pathogen kill rates ...
(Date:3/31/2015)... RnRMarketResearch.com adds "Pemphigus - ... of 68 pages with latest updates, data and ... The report "Pemphigus - Pipeline Review, H1 2015" report ... for Pemphigus , complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ...
Breaking Medicine Technology:Eurpoean Automatic External Defibrillators (Semi-Automated, Fully-Automated) Market 2015-2019 - Pre-Hospitals, Public Access Market, Hospitals, Alternate Care Market, Home Analysis 2Eurpoean Automatic External Defibrillators (Semi-Automated, Fully-Automated) Market 2015-2019 - Pre-Hospitals, Public Access Market, Hospitals, Alternate Care Market, Home Analysis 3VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 2VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 3VA Funded Study Validates Continuous UV-C Technology For Pathogen Reduction 4Pemphigus Therapeutic Development and Pipeline Review H1 2015 2Pemphigus Therapeutic Development and Pipeline Review H1 2015 3Pemphigus Therapeutic Development and Pipeline Review H1 2015 4
Cached News: