HOME >> MEDICINE >> NEWS
Drug combination proves effective against myeloma in Phase I trial

BOSTONTwo "new generation" drugs for the bone marrow cancer multiple myeloma may work even better together than they do individually, according to the results of a multicenter Phase I clinical trial to be presented by Dana-Farber Cancer Institute scientists at the annual meeting of the American Society of Hematology in Orlando, Fla.

The trial the first and largest reported to date to test the drugs bortezomib (Velcade) and lenalidomide (Revlimid) in combination involved 38 myeloma patients whose disease had recurred after previous treatment and was progressing despite other therapies.

Participants were divided into groups that received successively higher doses of the drugs. Some also received dexamethasone, a standard myeloma medication which adds to the effects of both bortezomib and lenalidomide, if the combination alone no longer controlled their disease.

The researchers, led by Paul Richardson, MD, and Ken Anderson, MD, of Dana-Farber, found that 58 percent of 36 evaluable patients responded to lenalidomide and bortezomib, including six percent who had complete remission, despite being heavily pre-treated and, in most cases, having received both classes of drug before. The median length of remission was six months, with some patients having disease control for up to two and a half years. The combined therapy also produced only mild fatigue or peripheral neuropathy (nerve damage signaled by tingling or numbness), researchers found. Patients who received dexamethasone because their disease continued to progress on the drug combination found the additional drug tolerable, and it produced a response or disease stabilization in about three quarters of them.

"It is remarkable to see the combination prove both tolerable and engender such durable responses in resistant disease," Richardson says. "We are hopeful that this combination will prove to be a key therapeutic backbone in improving outcomes for our patients, both earl
'"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
11-Dec-2006


Page: 1 2

Related medicine news :

1. Phase II study shows combination improves survival of metastatic melanoma patients
2. Certain combination therapy found more effective for treating malaria in African children
3. To get blood pressure under control, combination of medicines may be best
4. Drug/intervention combinations offer benefit in severe CVD
5. Scripps research combination therapy obliterates new vessel growth in tumors and retinopathy
6. Drug combination slows progression of treatment resistant bone marrow cancer
7. Drug combination could reduce risk of severe asthma attacks
8. Transplant patients keep their new kidney longer with a CellCept-based drug combination
9. Rheumatoid arthritis patients can benefit from Enbrel in combination with methotrexate
10. New combination therapy after surgery improves survival for pancreatic cancer patients
11. International study launched testing new drug combination to cut cardiovascular disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Drug combination proves effective against myeloma Phase trial

(Date:5/22/2013)... URBANA What effect does a father,s depression have on ... level of emotional intimacy in their marriage, their children benefit, ... is interacting with their child, they need to be able ... to his developmental stage and abilities, and notice whether he ... difficulty doing that," said Nancy McElwain, a U of I ...
(Date:5/22/2013)... IL A new study suggests that disturbed ... of depression and greater uncertainly about future success. ... and teachers appears to have a protective effect. ... significantly associated with depressed mood and greater uncertainty ... from parents and from teachers were associated with ...
(Date:5/22/2013)... drugs to the "power plants" that make energy to ... to preventing emergence of the drug-resistant forms of cancer ... reporting. That,s the conclusion of a new study published ... , Shana Kelley and colleagues explain that doxorubicin and ... genes inside the nucleus of cancer cells. Cancer cells ...
(Date:5/22/2013)... The newest member of TeethWhiteningforFree.com is Dr. ... Alabama graduate, Dr. Sanderson provides professional dental care to ... he extends complimentary teeth whitening to his patients who ... up. Only a dental professional can decide if the ... , Teeth whitening is an easy way ...
(Date:5/22/2013)... Slip and fall hazards are a common ... factors. A December 2010 CDC (Centers for Disease Control ... most common: contaminants on the floor, poor drainage problems, ... and lack of handrails (i). Common injuries resulting from ... muscles, fractures, broken bones, spinal cord injuries , ...
Breaking Medicine News(10 mins):Health News:Good marriage can buffer effects of dad's depression on young children 2Health News:Parent and teacher support protects teens from sleep problems and depression 2Health News:Dr. James Sanderson, Jr. Of SanDentistry in Hoover, Alabama Joins the TeethWhiteningforFree.com Family 2Health News:Law Firm Releases Slip and Fall Accident Informational Graphic to Show the Frequency and Cost of These Incidents 2Health News:Law Firm Releases Slip and Fall Accident Informational Graphic to Show the Frequency and Cost of These Incidents 3
(Date:5/22/2013)... 22, 2013 Pomerantz Grossman Hufford ... on behalf of investors of Intuitive Surgical, Inc. ("Intuitive ... (CUSIP: 46120E602) who purchased Intuitive Surgical common stock between ... Period"). Such investors are advised to contact ... or 888-476-6529, ext. 237. The investigation concerns ...
(Date:5/22/2013)... ORLEANS , May 22, 2013 ... for commercially-insured patients with Type 2 diabetes, while ... to improve health outcomes and can lead to ... presented at the International Society for Pharmacoeconomics and ... The two studies, sponsored by Valeritas, makers ...
(Date:5/22/2013)... TOKYO , May 22, 2013 ... Daiichi Sankyo Co., Ltd. (hereafter, Daiichi Sankyo), announced ... taken in recent years to address past conduct ... ). Daiichi Sankyo continues to ... correct the conduct of the past which led ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Intuitive Surgical, Inc. - ISRG 2Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 2Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 3Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 4Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 5Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 6
Cached News: