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Drug-eluting and absorbable stents push interventional frontiers

ATLANTA, GA (March 13, 2006) -- Medicated stents that prevent arterial renarrowing are offering hope to patients with certain types of cardiovascular disease, while a novel stent that slowly dissolves into the artery wall is proving to be a safe alternative to conventional devices, according to research presented today at the American College of Cardiology's inaugural Innovation in Intervention: i2 Summit 2006 in Atlanta, Ga. A separate study tests the best approach to prevent blood clots in patients with acute coronary syndromes. Innovation in Intervention: i2 Summit is an annual meeting for practicing cardiovascular interventionalists sponsored by the American College of Cardiology in partnership with the Society for Cardiovascular Angiography and Interventions.

Prospective, Randomized Comparison of Routine Upfront Initiation versus Selective Use of Glycoprotein IIb/IIIa Inhibitors in Patients with Acute Coronary Syndromes: The ACUITY Timing Trial

In patients with acute coronary syndromes, doctors are unclear about whether it is better to give glycoprotein IIb/IIIa inhibitors (GPI, which prevents platelets from clumping together to form a blood clot) to all patients in the emergency room, or wait for the results of angiography and give GPI only if angioplasty is needed to restore blood flow to the heart. The Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) Timing trial will answer that question.

Acute coronary syndrome (ACS) is an umbrella diagnosis that encompasses both unstable angina and a type of heart attack known as non-ST elevation myocardial infarction (NSTEMI). Today, drug therapy typically consists of aspirin, clopidogrel, heparin, and a glycoprotein IIb/IIIa inhibitor (GPI), each of which interferes with a specific step in blood clotting. Patients also typically have an angiography within a few days to determine whether further, invasive treatment with angioplasty or surgery is needed. '"/>


13-Mar-2006


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