Drug/intervention combinations offer benefit in severe CVD

rdiac death, heart attack, transplantation or re-hospitalization for cardiac reasons.

The study found that patients with poor LV function who received FDG PET imaging yielded fewer cardiac events over the course of a year compared with patients who received standard care (HR=0.81) but this did not reach statistical significance. However, among those patients who had not recently had an angiography X-ray exam, the PET-guided therapy significantly reduced cardiac death rates compared to those who received standard care (HR=0.4).

"Overall the study was too small to detect a significant benefit with PET imaging. With subsequent analysis, our results suggest that physician decisions about therapies for left ventricular dysfunction could be more accurate and effective with the use of imaging technologies like PET-guided therapy, particularly to manage disease in patients without a recent angiography," said Robert Beanlands, M.D., of the University of Ottawa Heart Institute, and lead author of the study. "Long-term follow up will determine whether or not these benefits are sustained and cost effective."

Dr. Beanlands will present his study on Monday, March 26, at 4:45 p.m. in Hall A.

A Phase III International Study to Assess the Safety and Efficacy of Nitric Oxide Synthase Inhibition with Tilarginine Acetate Injection in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction (Presentation Number: 412-8)

Cardiogenic shock (CS) is one of the most common causes of death among hospitalized patients with acute myocardial infarction (AMI). The TRIUMPH Study tested whether nitric oxide synthase (NOS) inhibition with Tilarginine Acetate (TAI) would reduce mortality with refractory CS, despite an open infarct-related artery. The TRIUMPH study will be simultaneously published in the Journal of the American Medical Association (JAMA) and will appear in the March 28 print issue.


Contact: Leslie Humbel
American College of Cardiology

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