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Drug/intervention combinations offer benefit in severe CVD

ugh the early mortality rate remains high in this condition, an important finding of this study is that functional capacity was quite good in survivors, even though these patients were very high risk based on persistence of cardiogenic shock after angioplasty and requirement for multiple vasopressor drugs.

"Preliminary findings in prior small studies looked positive, but the use of TAI in this largest trial of cardiogenic shock patients ever conducted showed no impact on mortality in these patients," said Judith S. Hochman, of the New York University School of Medicine, and Chair of the study. "Further investigation is needed to provide more options in treating this high-risk population."

Dr. Hochman will present her study on Monday, March 26, at 5:00 p.m. in Hall A


Blood Pressure Control Is an Independent Predictor of Short-term Mortality in Cardiac Surgery Patients: Analysis From the Three Randomized ECLIPSE Trials (Presentation Number: 412-5)

It is common but undesirable for a patient to experience excessively high or low blood pressure control during this time would improve clinical outcomes. The ECLIPSE trial (Evaluation of CLevidipine In the Postoperative Treatment of Hypertension Assessing Safety Events), was designed to compare the safety of clevidipine to two standard blood pressure therapies, nitroglycerin and sodium nitroprusside and a less-often used therapy, nicardipine. In three separate open-label trials conducted by researchers from Duke University Medical Center in Durham, N.C., patients undergoing cardiac surgery were equally randomized to receive clevidipine versus nitroglycerin, nitroprusside or nicardipine. Systolic blood pressure was monitored for 24 hours and the magnitude and duration of excursions outside of pre-defined acceptable ranges (85-145 mmHg pre- and post-operatively, and 75-135 mmHg intra-operatively) were determined by the area under the curve (AUC). Median AUC valu
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Contact: Leslie Humbel
lhumbel@spectrumscience.com
504-613-2418
American College of Cardiology
26-Mar-2007


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