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Drug/intervention combinations offer benefit in severe CVD

es were calculated for each treatment and multiple logistic regressions were used to estimate the risk of death within 30 days predicted by AUC values, adjusting for other risk variables.

The investigators found that an average blood pressure excursion of one mmHg per minute for 60 minutes resulted in a 20 percent increased 30-day mortality risk, and the risk rose rapidly for each additional 1 mmHg/min -- an excursion of 5 mmHg/min for 60 minutes was associated with a 146 percent increased risk of death.

A second, separate analysis showed that median perioperative blood pressure excursions were significantly lower for clevidipine than nitroglycerin and nitroprusside (p<0.05). Blood pressure excursions were the same for clevidipine and nicardipine, though that comparison was restricted to the post-operative period, since nicardipine is not generally used during surgery due to its slower onset of action and prolonged offset of action. In all three trials, the different treatment groups had similar clinical outcomes in the rate of death, stroke, heart attack and kidney dysfunction.

"The results of this study show that blood pressure control is a significant predictor of increased 30- day mortality, so managing perioperative hypertension is extremely important," said Solomon Aronson, M.D., of Duke University Medical Center and lead author on this study. "In addition, we found that risk rises rapidly for each additional level of digression in blood pressure levels, and clevidipine provides better overall control than current blood pressure therapies."

Dr. Aronson will present his study on Monday, March 26, at 4:15 p.m. in Hall A. He will present additional data from the ECLIPSE Trial on Tuesday, March 27 at noon, in the same location.


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Contact: Leslie Humbel
lhumbel@spectrumscience.com
504-613-2418
American College of Cardiology
26-Mar-2007


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