The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> MEDICINE >> NEWS
Drug may fight lupus and atherosclerosis simultaneously

WINSTON-SALEM, N.C. People with lupus are prone to premature accelerated atherosclerosis. Now scientists at Wake Forest University School of Medicine think they have a way to prevent or decrease this atherosclerosis and prevent heart attacks.

"Premature accelerated atherosclerosis is one of the leading causes of death and disability in lupus," said Nilamadhab Mishra, M.D., a rheumatologist at Wake Forest University Baptist Medical Center. Using a drug called Trichostatin A (TSA) "may prevent or decrease premature atherosclerosis in lupus."

Mishra presented his findings today (Nov. 16) at the American College of Rheumatology meeting in San Diego.

The findings represent a merger of two lines of Mishra's animal research using TSA one showing that the drug reduced lupus symptoms, especially inflammation of the kidneys and enlarged spleens, and the other showing that TSA was effective against atherosclerosis.

Mishra was joined in the atherosclerosis research by several leading scientists in the Medical School's long-standing atherosclerosis research program.

Their research uses a mouse that was created to be prone to atherosclerosis when fed a diet high in cholesterol and with 10 percent of calories from palm oil, one of the more dangerous dietary vegetable fats since it is high in saturated fat.

Among the atherosclerosis researchers were John S. Parks, Ph.D., professor of comparative medicine, and Richard St. Clair, Ph.D., professor of pathology and head of the Section on Comparative Medicine.

For 12 weeks, the researchers fed a high-fat, high-cholesterol diet to two groups of the atherosclerosis-prone mice. One group got injections of TSA from the time they went on the diet, while the other group got no TSA. The TSA-treated group had markedly less atherosclerosis in key arteries, such as the aorta the body's main blood vessel and what plaque there was contained less cholesterol.

Scientists increasing
'"/>

Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
16-Nov-2005


Page: 1 2

Related medicine news :

1. UIC researchers to develop new drugs to fight bioterrorism
2. Case study: cross-cultural bioethics training program helps fight African brain drain
3. Nurse cells make life and death decisions for infection-fighting cells
4. Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu
5. GPs should lead chronic disease fight -- Top doctor
6. How insulin-producing cells develop -- new finding could help fight against diabetes
7. Alternative hormone treatment could help fight against breast cancer
8. US soldiers in Iraq fighting drug-resistant bacteria after injuries
9. Breastfeeding and good fats help new moms fight depression
10. Wrapping Gleevec fights drug-resistant cancer
11. Anti-dandruff compound may help fight epilepsy

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Drug may fight lupus and atherosclerosis simultaneously

(Date:11/24/2009)...lif.,Nov.24/PRNewswire/--Bionorica,aninternational...,announcedtodaytheavailabilityofneweducationalreso...shealth.Atipsheeton"StayingNaturallyHealthyduringt...,isnowavailableonthecompany,swebsiteat www.bionori...freesubscriptiontotheNaturalMomstipsheets,withcont...
(Date:11/24/2009)....,Nov.24/PRNewswire-FirstCall/--HealthSouthCorpora...heBankofAmericaMerrillLynch2009CreditConferenceinN...residentandTreasurerEdFaywillbespeakingonThursday,...stliveandwillbeavailableat http://investor.healths...HealthSouth ,, HealthSouthisthenation,slargest...
(Date:11/24/2009)...ent may help ward off peripheral artery disease, ...althDay News) -- Among people aged 75 and older, t...t heart attacks, stroke or death, a new study find...rbal remedy might help prevent the leg-circulation...er. , Ginkgo contains nutrients called flavonoi...
(Date:11/24/2009)...ing improves heart prospects, but cancer risk rema...) -- A new study offers yet more proof that smokin...ase and cancer. , Researchers followed 12,152 A...ers smokers and nonsmokers for three years. During...ikely to die of cancer, 2.26 times more likely to ...
(Date:11/24/2009)... to the falls that plague older adults, study find...) -- Falls are a leading cause of death among olde...c pain contributes to those accidents. , "Pain ...ess, and is associated with mobility limitations t...rote. , "Chronic pain, no matter how we measure...
Breaking Medicine News(10 mins):Health News:Bionorica Offers Expert Resources, Health Tips for 'Natural Moms' 2Health News:Ginkgo Won't Prevent Heart Attack, Stroke in Elderly 2Health News:Ginkgo Won't Prevent Heart Attack, Stroke in Elderly 3Health News:Smokers Double Their Risk for Heart Disease 2Health News:Chronic Pain Trips Up Seniors 2Health News:Chronic Pain Trips Up Seniors 3
(Date:11/24/2009)...-FirstCall/--NeurogesX,Inc.(Nasdaq: NGSX ),abiopha...izingnovelpainmanagementtherapies,todayannouncedth...ectiveNovember19,2009.Mr.Orwinisa20-yearsalesandma...beeninstrumentalinthelaunchofseveralimportantthera...President,BioOncologyBusinessUnitatGenentech,Inc.,...
(Date:11/23/2009)...tCall/--HealthWarehouse.com,Inc.(OTCBulletinBoard:...itsfinancialresultsforthethirdquarterendedSeptembe...6,721,drivenbyheavygrowthinprescriptionsalesandpha...-yearto34.6%andthenetlossforthequarterwas$619,114c...eptember30,2008. ,, "Wecontinuetoseeconsumerstr...
(Date:11/23/2009)...theChicagoarea,sleadingBoardCertifiedDiagnosticRad...ng,couplingthelatesttechnologyindigitalmammography...ohavethefullrangeofdigitalimagingcompleted,diagnos...ce.Drs.AhmedFaragandJoanWerberaredeliveringthispat...tforanappointmentcommonlyfoundinChicago,fromtheirn...
Breaking Medicine Technology:NeurogesX Appoints Seasoned Sales and Marketing Executive as New Board Director 2NeurogesX Appoints Seasoned Sales and Marketing Executive as New Board Director 3HealthWarehouse.com, Inc. Announces Third Quarter Financial Results; Revenues, Margins, and Orders Shipped Increase Over Third Quarter 2008 2HealthWarehouse.com, Inc. Announces Third Quarter Financial Results; Revenues, Margins, and Orders Shipped Increase Over Third Quarter 2008 3Researcher physician and teacher Phil Gold to be inducted into the Canadian Medical Hall of Fame 59813 1Researcher physician and teacher Phil Gold to be inducted into the Canadian Medical Hall of Fame 59813 2Researcher physician and teacher Phil Gold to be inducted into the Canadian Medical Hall of Fame 59813 3Cancer survivors may not be getting the help they need to stop smoking 59811 1Cancer survivors may not be getting the help they need to stop smoking 59811 2National Science Foundation Fellow uses ultrasound to research bog turtles 10434 1National Science Foundation Fellow uses ultrasound to research bog turtles 10434 2
Other News:
...ning a healthy weight in children may be one good ...ppy heart, a new study has found.......A study of ...ness and fatness levels showed that fatter youths ...evels of triglycerides and higher ratios of total ...
...ENTO, Calif.) -- In recent years, American hospita...zed, evidence-based measures of clinical performan... attacks, heart failure, and pneumonia. But an edi...England Journal of Medicine, says it's not clear h...
...hers at the University of Edinburgh have begun a y... ways of helping elderly people to maintain their .... The study will draw in volunteers from central a...ons at the Royal Infirmary.......The group of 40 v...
...is losing significant numbers of its doctors to th...on, says a letter in this week's BMJ.......Followi...registered with the UK's General Medical Council i...ear. The Scandanavian countries are also a popula...
health news:Healthy weight means healthier blood lipid profile in children, study finds 2health news:Healthy weight means healthier blood lipid profile in children, study finds 3health news:Efforts to improve hospital care 2health news:Efforts to improve hospital care 3health news:Efforts to improve hospital care 4
...t. 16 Children exposed to alcohol in the womb con... 14, University of Pittsburgh researchers report.....s who consume considerably less than an average of...growth deficits and that exposure, as early as the...
...r Disease Control and Prevention has awarded $4.5 ...partnership with UCSF's AIDS Research Institute, t..., Training, and Evaluation (CIASTE). The partners...'s Center for AIDS and STDs through its Internatio...
...alif.) -- The unprecedented increase in autism in ... artificial factors, such as misclassification and...arge statewide epidemiological study......."Specul...as led some to try to explain it away as a statist...
... wrong in the NHS the official reaction is to set ...s that many inquiry reports highlight similar sort...ays learnt.......Researchers at the University of ...o 2002 to explore their use and impact in the NHS....
health news:Children exposed to alcohol before birth show deficits 2health news:The CDC has awarded $4.5 million to UCSFS Institute for Global Health 2health news:M.I.N.D. Institute study confirms autism increase 2