HOME >> MEDICINE >> NEWS
Drug to block mother-to-child HIV transmission induces resistance more often than previously thought

The incidence of drug resistance associated with single-dose nevirapine, a drug used to prevent mother-to-child transmission of HIV-1, may be substantially higher than previously thought and of particular risk for those infected with HIV-1 subtype C, according to three new studies published in the July 1 issue of The Journal of Infectious Diseases, now available online.

A single dose of nevirapine given to an HIV-infected pregnant woman during delivery, and another given to her newborn, can cut the rate of mother-to-child HIV transmission in half. The relative simplicity and affordability of single-dose nevirapine have made it the drug of choice for prevention of mother-to-child transmission in many developing countries.

This new research expands understanding of the risks of drug resistance associated with single-dose nevirapine, but as noted by all three research groups, the clinical implications for patients are not yet clear. More research will be needed to determine whether nevirapine used to prevent mother-to-child transmission affects the chances of successful treatment later with nonnucleoside reverse transcriptase inhibitors, the class of drug to which nevirapine belongs.

Two of the studies analyzed the incidence of nevirapine-associated resistance using laboratory tests more sensitive than standard genotypic assays. In the first, researchers led by Jeffrey A. Johnson, PhD, of the Centers for Disease Control and Prevention, used a new, very sensitive technique to detect resistance mutations in samples of HIV-1 obtained from 50 South African women before and after treatment with single-dose nevirapine. Using a less-sensitive conventional technique called sequence analysis, researchers had previously estimated that viral resistance to nevirapine emerged in approximately 40 percent of women after receiving the single-dose therapy. In contrast, Dr. Johnson and colleagues concluded that resistance emerges in at least 65 percent of women a
'"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
1-Jun-2005


Page: 1 2 3

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Future therapies for stroke may block cell death
3. Scavenger cells may have role blocking obesity, Stanford study shows
4. Computer scientist reveals the math and science behind blockbuster movies
5. First-degree fetal heart block may be reversible
6. MR angiography highly accurate in detecting blocked arteries
7. Scientists stop colon cancer growth in mice by blocking just one enzyme
8. A world first in the treatment of a young patient with a completely blocked yet vital heart artery
9. People often forgo using lifesaving beta blockers despite health insurance
10. Drug could change the standard treatment during procedures to clear blocked arteries
11. Tumor necrosis factor blockers may not cause cancer after all

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... VA (PRWEB) , ... December 07, 2016 , ... ... are celebrating the passage of the most comprehensive mental health systems reform legislation ... the support of the President, and the commitment of our elected officials to ...
(Date:12/7/2016)... ... December 07, 2016 , ... OC87 Recovery Diaries ... schizophrenic mother in a unique, personal perspective through animation. , That woman ... addictive disorders at her private psychotherapy practice. Sheri’s mother, Pearl, lived with schizophrenia. ...
(Date:12/7/2016)... CT (PRWEB) , ... December 07, 2016 , ... A ... prompted an outpouring of comments on social media that offer a rare glimpse into ... psychiatrist, leading ADHD authority and New York Times bestselling author, has described people with ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Cliff Hart Agencies, a ... Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, and Farmington Hills, is announcing a ... brain tumor. , Jason Bauer and his family are longtime members of the ...
(Date:12/7/2016)... NY (PRWEB) , ... December 07, 2016 , ... A. ... business owners and families throughout the Five Boroughs, is launching a charity drive to ... works to continue the traditions and spirit of marines and Navy FMF Corpsmen. Working ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Mich. , Dec. 7, 2016 A new ... readied for human clinical trials in search of the world,s ... following publication of research findings today in the journal ... hope this will be a watershed moment for millions of ... Ph.D. , director of Van Andel Research Institute,s ...
(Date:12/7/2016)... , Dec. 7, 2016 REPORT OBJECTIVES ... Intelligence (2011-2020)" provides market intelligence on a market ... (2011-2020) has been provided in the report. The ... 1) comprehensive global market intelligence through detailed segmentation, ... dynamics, industry structure and developments, market situation, trends, ...
(Date:12/7/2016)... BETHESDA, Md. , Dec. 7, 2016 /PRNewswire/ ... Bio" or the "Company"), a biotechnology company developing ... today announced that the Nasdaq Staff has not ... violations of Listing Rules previously reported, and the ... voluntarily withdraw the Company,s common stock from listing ...
Breaking Medicine Technology:
Cached News: