HOME >> MEDICINE >> NEWS
Drug to block mother-to-child HIV transmission induces resistance more often than previously thought

The incidence of drug resistance associated with single-dose nevirapine, a drug used to prevent mother-to-child transmission of HIV-1, may be substantially higher than previously thought and of particular risk for those infected with HIV-1 subtype C, according to three new studies published in the July 1 issue of The Journal of Infectious Diseases, now available online.

A single dose of nevirapine given to an HIV-infected pregnant woman during delivery, and another given to her newborn, can cut the rate of mother-to-child HIV transmission in half. The relative simplicity and affordability of single-dose nevirapine have made it the drug of choice for prevention of mother-to-child transmission in many developing countries.

This new research expands understanding of the risks of drug resistance associated with single-dose nevirapine, but as noted by all three research groups, the clinical implications for patients are not yet clear. More research will be needed to determine whether nevirapine used to prevent mother-to-child transmission affects the chances of successful treatment later with nonnucleoside reverse transcriptase inhibitors, the class of drug to which nevirapine belongs.

Two of the studies analyzed the incidence of nevirapine-associated resistance using laboratory tests more sensitive than standard genotypic assays. In the first, researchers led by Jeffrey A. Johnson, PhD, of the Centers for Disease Control and Prevention, used a new, very sensitive technique to detect resistance mutations in samples of HIV-1 obtained from 50 South African women before and after treatment with single-dose nevirapine. Using a less-sensitive conventional technique called sequence analysis, researchers had previously estimated that viral resistance to nevirapine emerged in approximately 40 percent of women after receiving the single-dose therapy. In contrast, Dr. Johnson and colleagues concluded that resistance emerges in at least 65 percent of women a
'"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
1-Jun-2005


Page: 1 2 3

Related medicine news :

1. Scientists train nano-building blocks to take on new shapes, as reported in Science
2. Future therapies for stroke may block cell death
3. Scavenger cells may have role blocking obesity, Stanford study shows
4. Computer scientist reveals the math and science behind blockbuster movies
5. First-degree fetal heart block may be reversible
6. MR angiography highly accurate in detecting blocked arteries
7. Scientists stop colon cancer growth in mice by blocking just one enzyme
8. A world first in the treatment of a young patient with a completely blocked yet vital heart artery
9. People often forgo using lifesaving beta blockers despite health insurance
10. Drug could change the standard treatment during procedures to clear blocked arteries
11. Tumor necrosis factor blockers may not cause cancer after all

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... ... January 19, 2017 , ... ... of Proctology) announced today the opening of 3 medical offices specializing specifically ... Hemorrhoids Center of Los Angeles (Beverly Hills), Hemorrhoids Center of Newport Beach, ...
(Date:1/18/2017)... ... ... A recent video posting of a new fidget product gathered online momentum ... relieve stress and anxiety. No one was more surprised than Think Ink Pen ... a successful Kickstarter campaign raising $67,000 on the popular crowdfunding platform. “We’ve been ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... From a ... are released almost daily linking gut health to chronic disease, mental health and general ... Year ” as an important resolution to consider. , For one Charlottesville restaurant, good ...
(Date:1/18/2017)... ... January 18, 2017 , ... The VA Maryland Health ... on a research project focused on multiple sclerosis (MS). Led by Christopher M. ... to control the disease without compromising normal immune function that often occurs during ...
(Date:1/18/2017)... ... January 18, 2017 , ... Specialty ... specialty pharmacists and pharmacy professionals, has teamed up with Ochsner Health System ... announced Brian Haug, president of Pharmacy Healthcare Communications, LLC, publishers of Specialty ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)...  Magnetic Insight Inc., leader in magnetic particle ... with inviCRO LLC to develop intuitive image analysis ... on inviCRO,s VivoQuant™ visualization and post processing software ... MPI solution package with the Momentum MPI imaging ... in vivo. MPI is a groundbreaking ...
(Date:1/18/2017)... Minn. , Jan. 18, 2017  EnteroMedics ... of medical devices using neuroblocking technology to treat ... announced the pricing of an underwritten public offering ... prior to deducting underwriting discounts and commissions and ... offering is comprised of Class A Units, priced ...
(Date:1/18/2017)... Calif. , Jan. 18, 2017  Adaptive Sound Technologies, ... today a new partnership with Hyatt Place Nashville/Downtown to ... providing ASTI LectroFan sleep therapy machines in over two ... of the most important parts of having a great ... general manager of Hyatt Place Nashville/Downtown. "We,re pleased to ...
Breaking Medicine Technology:
Cached News: