HOME >> MEDICINE >> NEWS
Drug treats 'water intoxication' faster, more effectively

CHICAGO -- Results of the two largest studies on hyponatremia, SALT-1 and SALT-2, presented Nov. 14 at the American Heart Association's Scientific Sessions in Chicago, found that the investigational drug tolvaptan treated hyponatremia water intoxication -- faster and more effectively than available treatments.

"These studies proved for the first time that hyponatremia, which is associated with poor outcomes, can be treated effectively with an oral drug that has no significant side effects," said Mihai Gheorghiade, M.D., professor of medicine at Northwestern University's Feinberg School of Medicine, who presented the results of the studies at the AHA meeting.

Hyponatremia is a relatively common electrolyte disorder. It affects a wide spectrum of patients including those with liver problems, heart failure and the elderly. It also may affect marathon runners.

Occurring in 15 to 20 percent of hospitalized patients with heart failure, hyponatremia is the opposite of dehydration. Known as "water intoxication," the condition occurs when serum sodium concentration in the blood falls to dangerously low levels causing cells in the body to stop excreting water. Normal serum sodium levels are between 135 and 145 millimoles per liter (mmol/L). Hyponatremia occurs when serum concentration drops to less than 135 mmol/L. In severe cases, it can lead to cerebral edema and even death.

Yet current therapies for hyponatremia are often ineffective and poorly tolerated. The two SALT studies will be published in the November 16 issue of the New England Journal of Medicine and presented at the AHA meeting offer promising information.

Robert Schrier, M.D., professor of medicine of the University of Colorado, Denver, and Gheorghiade and their colleagues at other institutions, found that tolvaptan, a V2-receptor antagonist developed by Otsuka Pharmaceutical Co., Ltd. and Otsuka Maryland Research Institute, Inc., began to improve patient
'"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
14-Nov-2006


Page: 1 2

Related medicine news :

1. Common blood pressure drug treats muscular dystrophy in mice
2. Facial resurfacing treats precancerous skin lesions, may help prevent skin cancer
3. Therapy program export treats borderline personality disorder
4. Modified Atkins diet effectively treats childhood seizures
5. No sweat CT-guided injection treats embarrassing hand condition
6. Trauma victims survival may depend on which trauma center treats them
7. Stem cell therapy successfully treats heart attack in animals
8. One-a-day tablet treats common infection among head and neck cancer patients
9. Increasing benefit seen in novel drug that treats Gleevec resistance
10. Diabetics with high blood pressure benefit from water pills
11. BC catalyst discovery promises faster, cheaper drug production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/14/2020)... ... February 14, 2020 , ... “The American ... weight, skin texture and discoloration, and lines and wrinkles. And the treatments they ... offering some great specials in February specifically to address the areas our patients ...
(Date:2/13/2020)... ... February 13, 2020 , ... Charles ... Assisted Living in Phoenix, AZ announced today his re-election as the President of ... Living Facility Managers (NCIA). , As President of the State Board, Villafranca ...
(Date:2/13/2020)... ... February 13, 2020 , ... ... fourth consecutive year, his budget proposes substantial, damaging cuts to foreign affairs, global ... cut to development and diplomacy, slashes USAID global health programs by $3.1B, and ...
(Date:2/11/2020)... ... ... There are many reasons why Care to Care is a leader in ... above our competitors is our true Peer to Peer process. At Care to Care, ... experience. We understand that it is impossible to create criteria to cover every clinical ...
(Date:2/11/2020)... ATLANTA (PRWEB) , ... February 11, 2020 , ... The wait is finally over. The ... Novo Nordisk. For years, this squad has been associating professional sports to a truly special ... in the world made up entirely of athletes with diabetes. They decided to take on ...
Breaking Medicine News(10 mins):
(Date:2/19/2020)... DURHAM, N.C. (PRWEB) , ... February 19, 2020 , ... ... illustrate the presence of oxygen-deprived clusters throughout the damaged site of a compressed spinal ... the use of a viral vector to target the oxygen-deprived sites enhances the injured ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... of platforms. Molecular diagnostics platforms are increasingly becoming popular as they enable accurate ... 2019, the market for molecular cancer diagnostics, including histology and assays, reached $1.6 ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... performing healthcare provider organizations with the release of its annual GHX “Best ... amongst North America’s premier hospitals for their ability to demonstrate improved operational performance ...
Breaking Medicine Technology:
Cached News: