Dynamic duo: Combination therapy reverses type 1 diabetes

Researchers have now carefully crafted a combination therapy that reverses recent-onset type 1 diabetes in 2 animal models of disease. By combining an oral with an intranasal therapy for type 1 diabetes that have individually shown beneficial, but limited, effects in previous studies, Matthias von Herrath and colleagues at the La Jolla Institute for Allergy and Immunology deliver a one-two punch, and prove that, in this case, 2 treatments work together better than one. The study appears online on April 20 in advance of print publication in the May issue of the Journal of Clinical Investigation.

In patients with type 1 diabetes, the autoimmune response destroys insulin-producing cells (beta cells) in pancreatic islets, thereby subjecting these individuals often children or young adults to a lifetime of insulin injections. To prevent disease, autoreactive immune cells need to be suppressed or eliminated without negative side-effects. One treatment strategy that has been shown to suppress beta cell killing is the delivery of an antibody against the CD3 molecule expressed on most T cells. This antibody promotes the function of regulatory T cells (Tregs), which put the brakes on an overaggressive immune response. However, chronic "body-wide" suppression of the immune system in this way puts patients at risk for malignancies or reactivation of dormant viral infections, consequently dampening enthusiasm for this monotherapeutic approach.

One of the critical questions that has remained is how do we prevent immune responses against only insulin-producing cells? Promising data in animal models has shown that it is possible to deliver beneficial immune modulatory molecules to the pancreatic islets by inducing islet antigenspecific Tregs. However, this intervention only appears effective early in the pre-diabetic stage.

In their JCI study, von Herrath and colleagues show that combination treatment with a low-dose, orally-delivered CD3epsilon-specific a

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2

Related medicine news :

1. Dynamic sonography accurate in diagnosing muscle tears
2. Combination treatment stymies breast cancer growth
3. Combination therapy spares some head and neck patients from surgery
4. Combination of personality traits increases risk for heart disease
5. Combination therapy may improve survival for pancreatic cancer
6. Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
7. Combination of three new, high-powered MRI systems at PENN is a first in the US
8. Combination of interventions can substantially reduce incidence of malaria in people with HIV
9. Combination therapy improves AIDS-related lymphoma outcome
10. Combination treatment for brain cancer not detrimental to patients quality of life
11. Combination microbicides protect monkeys against HIV-like virus

Post Your Comments:

(Date:11/22/2019)... ... ... Serving Seniors , the nonprofit organization dedicated to helping low-income seniors throughout ... project from The San Diego Union-Tribune. , Founded in 1970, Serving Seniors has ... From senior advocacy and mental health programming to housing and nutritional meal services, the ...
(Date:11/21/2019)... Maine (PRWEB) , ... November 21, 2019 , ... ... are healthcare related. Consumers want healthcare information and therefore, AllKindsofTherapy.com average ... of facts like accreditation type, whether a therapist is licensed, clinical hours with ...
(Date:11/21/2019)... ... November 21, 2019 , ... CONTACT: ... Middlesex Health Care Awarded the Golden Acorn by the Charter Oak State College ... for Charter Oak State College, Connecticut’s public online college, recently held its annual ...
(Date:11/20/2019)... ... November 20, 2019 , ... ... Specific Biomarkers In Vitro Assays’” by Eileen Mary Meagher has been named No. ... Fitness & Dieting, Religion & Spirituality, Family and General Practice, and Science & ...
(Date:11/19/2019)... GILBERT, Ariz. (PRWEB) , ... November 19, 2019 ... ... the new Isagenix International products will help consumers make and maintain ... company has debuted Collagen Bone Broth, IsaPro® Plant-Based Protein, and CBD Peppermint Oil ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... WESTCHESTER COUNTY, N.Y. (PRWEB) , ... November 19, 2019 , ... ... County hospices hosted their 10th annual inter-hospice countywide breakfast on Tuesday, November 12. The ... proudly served in all five branches of the military: Army, Navy, Air Force, Marines ...
(Date:11/19/2019)... ... November 19, 2019 , ... Dr. David Stoker recently welcomed Carla Crespo, MSHS, ... expertise in nonsurgical and body contouring procedures is recognized nationally, as she is a ... is among an exclusive group of experts in the U.S. who train injectors for ...
(Date:11/19/2019)... , ... November 18, 2019 , ... ... Health Biomarkers Using Cell-Based Assays” by Elizabeth Patric has been named No. 1 ... Holistic Medicine, Biochemistry, Microbiology, Nosology, Nursing Reference, Research and Theory, and Mind-Body Connection ...
Breaking Medicine Technology:
Cached News: