HOME >> MEDICINE >> NEWS
EVEREST data on use of tolvaptan published in JAMA and featured at ACC

PRINCETON, N.J., March 25, 2007-- Once-daily dosing with Otsuka's investigational oral medication tolvaptan, a vasopressin receptor antagonist, was associated with improvements in signs and symptoms of acutely decompensated heart failure (ADHF) in hospitalized patients receiving conventional care, without an adverse effect on their long-term survival versus placebo. These data are from the short- and long-term analyses of the international landmark trial Efficacy of Vasopressin antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) published in the March 28 issue of the Journal of the American Medical Association (JAMA). These data were presented at the American College of Cardiology's 56th Annual Scientific Sessions (ACC).

The phase 3 EVEREST trial, involving a total of 4,133 ADHF patients, represents three studies: a long-term outcomes trial evaluating patients after their discharge for a minimum of 60 days of treatment, and two identical, embedded short-term pivotal studies that examined tolvaptan compared to placebo over seven days of inpatient care or discharge, whichever came first.

Data from the two short-term studies documented that tolvaptan treatment yielded significantly greater improvements than placebo based on the primary endpoint (study A: p less than 0.001 and study B: p less than 0.001), which was the composite score of changes in patient-assessed global clinical status and changes in body weight at day seven or discharge. Long-term tolvaptan use did not differ from placebo on either of the study's two primary endpoints: deaths from all causes (p equal to 0.68) or from the combined endpoint of cardiovascular (CV) deaths or subsequent hospitalization for worsening HF (p equal to 0.55).

"Tolvaptan exhibited short-term symptomatic benefits in patients hospitalized with worsening heart failure," said investigator Marvin A. Konstam, M.D., chief of the Division of Cardiology at the Tufts- New England
'"/>

Contact: Debra Kaufmann
debra.kaufmann@otsuka.com
240-683-3568
Porter Novelli
27-Mar-2007


Page: 1 2 3 4 5

Related medicine news :

1. Is most published research really false?
2. Bayer and Onyx announce pivotal Nexavar kidney cancer study published in NEJM
3. In stroke, negative studies less likely to get published
4. Landmark study on diabetic foot infection published
5. New international standards for tuberculosis care published
6. Research published in the NEJM challenges 30-year-old standard of care for lupus patients
7. Newly published summer camp health guideline advises parents, camp directors
8. Child sex abuse policy recommendations published in Science magazine
9. Aqueous Humor Outflow featured in Investigative Ophthalmology & Visual Science
10. Health effects of functional foods featured during four-day symposium, Sept. 10-13
11. Rare, historic medical cartoons to be featured in film series

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: EVEREST data use tolvaptan published JAMA and featured ACC

(Date:7/31/2014)... NV (PRWEB) July 31, 2014 Weblify has ... after 4 years of development and testing. The result ... monetized websites in as little as 5 minutes without knowing ... full Weblify review , Shane Michaels, an SEO expert, agrees ... quickly. “I’ve seen a lot of web site builders ...
(Date:7/31/2014)... Angeles, CA (PRWEB) July 31, 2014 ... Southern California’s best Plastic Surgeons to consumers considering cosmetic ... recommended by their peers whose goal is to educate ... The doctors are selected through a validated referral system ... who are the best in their respective fields. ...
(Date:7/31/2014)... July 31, 2014 Daily Gossip indicates ... pain killers for this health problem. However, this is ... new program was created by Peter Bansby, who decided ... sufferers from all over the world find a unique ... people wish to view pros and cons from a ...
(Date:7/31/2014)... 31, 2014 Current residents at ... program in Flagstaff, AZ, learn to kayak safely for ... and paddle strokes in preparation for next week's wilderness ... think that [the kayaking course] teaches [residents] to listen ... with in their early part of their sobriety," said ...
(Date:7/31/2014)... CarePoint Health is proud to ... has joined our network, CarePoint Health Medical Group. ... Hundreds of highly skilled and experienced physicians comprise ... top doctors and practices in Hudson County, representing ... represents CarePoint Health’s commitment to provide the highest ...
Breaking Medicine News(10 mins):Health News:Weblify Review Exposes Ricky Mataka And His New Site Building Platform 2Health News:Weblify Review Exposes Ricky Mataka And His New Site Building Platform 3Health News:The New Doctors’ Directory, Cosmetic Town Does the Research for Consumers of Plastic Surgeries 2Health News:Neuropathy Miracle Review Reveals Peter Bansby's Unique Cure Method 2Health News:Back2Basics Substance Abuse Residents Take Kayaking Class for the First Time 2Health News:Dr. Rizvi Joins CarePoint Health Medical Group 2
(Date:7/31/2014)... Xencor Inc. (NASDAQ: XNCR ), a ... the treatment of autoimmune diseases, asthma and allergic ... the second quarter ended June 30, 2014 and provided ... "In the second quarter, we presented preclinical data ... (ATS) demonstrating three novel mechanisms of action of ...
(Date:7/31/2014)...  Cepheid (NASDAQ: CPHD ) today announced that ... invited investors to participate via webcast. ... NY Wednesday, August 13, 2014 at 9.10 a.m. ... New York, NY Thursday, September 4, 2014 ... Webcasts To access the live webcasts for these events, please ...
(Date:7/31/2014)... Calif. , July 31, 2014  Alexza ... provided an update on its pipeline and new ... Alexza expects to initiate a Phase 2a study ... being developed for the management of patients with ... new Staccato -based product candidates for development ...
Breaking Medicine Technology:Xencor Reports Second Quarter 2014 Financial Results 2Xencor Reports Second Quarter 2014 Financial Results 3Xencor Reports Second Quarter 2014 Financial Results 4Xencor Reports Second Quarter 2014 Financial Results 5Xencor Reports Second Quarter 2014 Financial Results 6Xencor Reports Second Quarter 2014 Financial Results 7Xencor Reports Second Quarter 2014 Financial Results 8Cepheid to Webcast Upcoming Financial Presentations 2Alexza Provides Pipeline Update 2Alexza Provides Pipeline Update 3Alexza Provides Pipeline Update 4Alexza Provides Pipeline Update 5Alexza Provides Pipeline Update 6
Cached News: