Early release article from Annals of Internal Medicine

PHILADELPHIA (Jan. 20, 2006) Three case reports of liver problems after taking the antibiotic telithromycin (Ketek) are reported in Annals of Internal Medicine today.

Researchers at Carolinas Medical Center in Charlotte, N. C., say that one of the patients died; one required and received a liver transplant; and the third recovered from drug-induced hepatitis after the antibiotic was stopped.

The article, "Severe Hepatotoxicity of Telithromycin: Three Case Reports and Literature Review" will be published in the March 21, 2006, print edition of the journal. It was released early today online and is available to the public on Jan. 20, 2006, at http://www.acponline.org/journals/annals/hepatotoxicity.htm.

"These cases could represent an unusual clustering of a rare, idiosyncratic drug reaction at one medical center," said John S. Hanson, MD, an author and hepatologist with the liver transplant center at Carolinas Medical Center.

"However, the severity of liver injury in two of our patients warrants this report in the medical literature and will alert other physicians to this possible link with telithromycin."

Dr. Hanson said that, despite the three reports, "At this point, there is not enough data to indicate major changes in prescribing habits."

All cases have been referred to the FDA's Adverse Event Reporting System.

Patients taking Ketek should report symptoms such as malaise, weakness, or jaundice to their prescribing physicians.

Telithromycin was approved by the U.S. Food and Drug Administration in 2004 to treat acute bacterial infections from chronic bronchitis, acute bacterial sinusitis and community-acquired pneumonia.

Telithromycin, an antibiotic derived from the macrolide class of antibacterial agents, appears effective against some pneumonia strains resistant to other older antibacterials such as penicillin.

Contact: Susan Anderson
American College of Physicians

Page: 1 2

Related medicine news :

1. Early-childhood intervention may improve well-being through young adulthood
2. Early-morning Friday classes may prevent students from getting sloppy on thirsty Thursdays
3. Early education for the health care team -- Bringing nursing and medical students together
4. Early onset of poor bone mineralization revealed in children with cystic fibrosis
5. Early sex may lead teens to delinquency, study shows
6. Early switch to an aromatase inhibitor increases survival
7. Early results indicate radiofreqency ablation useful in treating ovarian cancer metastasis
8. Early statin therapy for patients with acute coronary syndromes reduces death, cardiovascular events
9. Early trial shows H5N1 influenza vaccine safe and effective in humans at low doses
10. Early warning test for Parkinsons receives national recognition
11. Early-onset of diabetes associated with increased risk of kidney disease and death before age 55

Post Your Comments:

(Date:8/31/2020)... ... ... your dear friend has cancer? , It’s hard to hear your doctor say the words ... the shock wears off, the questions and fears can be overwhelming. , How should I ... Words are failing me. I’m scared. I want to DO something. , We’ve talked to ...
(Date:8/31/2020)... ... August 31, 2020 , ... Want to get moving, break up your ... Foundation (CPARF) is thrilled to launch its fourth annual STEPtember campaign in the United ... STEPtember meets everyone wherever they are at this moment — encouraging people to move ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... of innovative higher-learning opportunities through high-quality, career-relevant, and affordable online education – is ... Psychology . , Among the first of its kind in the nation, ...
(Date:8/31/2020)... ... 2020 , ... The pandemic and topsy-turvy economic outlook continues to put financial strain on many ... to trim the fat from our monthly expenses and put more into savings, if possible. ... you have a financial safety net in place in case something were to happen to ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give ... is donating 10 percent of each hotel room booked with a special new rate ... & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... September 02, 2020 , ... ... Covid-19 , Advanced Penetration Technology, LLC, (APT) a Texas- and Indiana-based company ... non-prescription, Over The Counter (OTC) products, was today provided results of an ...
(Date:9/1/2020)... (PRWEB) , ... September 01, 2020 , ... ... and Director of Cosmetics and Laser Surgery at the University of Rochester Medical ... Surgery fellowship at SkinCare Physicians in Boston, with clinical faculty from the Harvard ...
(Date:9/1/2020)... ... ... Breast and ovarian cancers are common diseases that affect many women. ... 7,500 women per year) and 10% of ovarian cancers (about 2,000 women per year) ... detectable in the Women’s Excellence Genetic Testing Program. , Dr. Jonathan Zaidan, MD, FACOG, ...
Breaking Medicine Technology:
Cached News: