Eating foods with 'weak estrogens' may help reduce lung c...( beans and soy products chickpeas and r...),Health

beans and soy products, chickpeas and red clover), lignans (rye grains, linseeds, carrots, spinach, broccoli and other vegetables), and coumesterol (bean, peas, clover, spinach and sprouts). They also looked at phytosterols, a fourth group of plant-derived steroidal compounds that are believed to have estrogenic properties. These include vegetable oils, margarines, spreads, grains and certain fruits and vegetables.

The researchers divided consumption of these foods into quartiles, from highest use to lowest use, as measured against all participants. (Use was not calculated by precise quantities, like cups, and so guidelines on what constitutes the highest-lowest quartile consumption are not available.) They then compared the two groups, and among their findings were:

• Overall, consumption of phytoestrogens was statistically significantly higher in controls than in cases.
• The overall reduction in lung cancer risk was 46 percent for the highest intake of all phytoestrogens from food.
• For men, statistically significant trends were noted for each class of phytoestrogen, when they were consumed at the highest levels. For example, isoflavones reduced lung cancer risk by 44 percent, and lingans reduced the risk by 27 percent.
• In women, only intake of total phytoestrogens from food sources was statistically significantly higher in controls than in cases. High consumption of these foods reduced risk by 34 percent, but no effect was seen when individual classes of phytoestrogens were evaluated.

The researchers suggest that phytoestrogens may help protect against lung cancer development because they latch on to estrogen receptors that are present in both normal and malignant lung tissue, and this binding could exert a role in the regulation or deregulation of cancer growth. But they cannot say why women, in general, seemed to benefit less from eating high quantities of specific classes of food with phytoestrogens - as men do
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Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
27-Sep-2005

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