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es suggested that EGCG and gp120 both bind to the same spot on CD4 molecules.

"We have demonstrated clear evidence of high affinity binding of EGCG to the CD4 molecule. EGCG at concentrations equivalent to those obtainable by the consumption of green tea is able to significantly reduce the attachment of gp120 to CD4," the authors concluded. They added that the competitive binding properties of EGCG for the CD4 binding sites by gp120 may help researchers design new therapies to treat and prevent HIV infection. While EGCG may be effective against HIV in laboratory cells, much more research is needed to determine if it has potential in infected humans.

Abstract A-34 Epigallocatechin Gallate, Green Tea Catechin, Binds to T Cell Receptor, CD4
Nance, Christina; Williamson, Mike; Paulson, Susan; McCormick, Theron; Shearer, William


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25-May-2006


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