HOME >> MEDICINE >> NEWS
Enoxaparin beats unfractionated heparin as adjunct therapy for heart attacks

cardial Infraction. (ExTRACT-TIMI 25) study led by the TIMI Study Group (Boston).

"Based on the results of the ExTRACT-TIMI 25 trial, we believe that a strategy using enoxaparin is now the preferred anticoagulant regimen in heart attack patients who receive clot-busting drugs," said Eugene Braunwald, M.D., M.A.C.C., Distinguished Hersey Professor of Medicine, Harvard Medical School, Chairman, TIMI Study Group, Brigham and Women's Hospital.

Researchers found that enoxaparin reduced the combined risk of death and MI within 30 days by 17 percent. Similarly, enoxaparin reduced the 30-day risk of nonfatal repeat MI by 33 percent, and the 30-day combined risk of death, nonfatal MI, and urgent need to re-establish blood flow to the heart by 19 percent. All of the findings were highly statistically significant.

The trial enrolled 20,506 patients from 674 medical centers in 48 countries. All patients had ST-elevation MI (STEMI), a serious form of heart attack characterized by elevation of the "ST segment" on the electrocardiogram. They were treated with a fibrinolytic, or clot-busting, medication within six hours of first experiencing chest pain, and were then randomly assigned to receive therapy with enoxaparin or unfractionated heparin.

To make sure there was no unintended bias in interpreting the results, the trial used a double-blind, double-dummy design: study participants received both intravenous infusions and twice-daily injections without the physician or the patient knowing which contained the study medication and which was the placebo.

The rates of serious bleeding were lower overall than reported in prior trials. Patients who were treated with the enoxaparin strategy were more likely to experience major bleeding. However, when researchers calculated net clinical benefit, which takes into account both effectiveness and safety, the enoxaparin strategy was, on balance, associated with significantly better outcomes.
'"/>


14-Mar-2006


Page: 1 2 3

Related medicine news :

1. US beats Europe for hypertension treatment
2. For super-obese patients, duodenal switch beats gastric bypass
3. Efficacy and safety of Aripiprazole as adjunctive therapy in major depressive disorder
4. New data demonstrate effectiveness of LAMICTAL (lamotrigine) as adjunctive therapy
5. Chemotherapy with bevacizumab increases risk of blood clots in arteries
6. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
7. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
8. Hormone therapy offers new hope for ovarian cancer patients
9. Borderline personality disorder shows improvements with intensive psychotherapy
10. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
11. Chemotherapy may enhance the effectiveness of brain tumor vaccines

Post Your Comments:
(Date:7/28/2014)... HealthDay Reporter MONDAY, July 28, ... milliseconds to look at someone,s face and judge them good-looking ... certain facial features seem to trigger specific first impressions about ... the mouth, for example, appear directly linked to whether someone ... The study findings suggest that first impressions are fairly ...
(Date:7/28/2014)... Nashville, TN (PRWEB) July 28, 2014 ... successful Operation Military June . Renowned LASIK ... Military June" to provide significant funds and public ... active and retired military personnel and their families. ... we will proudly give nearly $5,000 to a ...
(Date:7/28/2014)... News) --,The more chronic medical conditions people have at ... a new study claims. Since nearly four ... at Johns Hopkins Bloomberg School of Public Health in ... in life expectancy are slowing in the United States. ... kidney disease and heart failure is now the norm ...
(Date:7/28/2014)... 28, 2014 SIMpalm helped its ... App is available on iTunes for download . Experience ... Audio Chef allows you to listen and cook along with ... way: simply get out the ingredients and equipment, press play, ... or prepare ingredients ahead of time, just relax and cook ...
(Date:7/28/2014)... Lake City, Utah (PRWEB) July 28, 2014 ... protein powders and drinks, announced that it will be ... drink line of products this summer. The additional flavors ... with clean pure taste-free protein , Inspire Pomegranate Razz ... Vanilla - flavor of soft-serve vanilla cone , Bariatric ...
Breaking Medicine News(10 mins):Health News:Facial Dimensions May Be Key to First Impressions 2Health News:Facial Dimensions May Be Key to First Impressions 3Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3Health News:Chronic Medical Conditions Can Shorten Seniors' Lives: Study 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2
(Date:7/28/2014)... Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC ) today ... webcast to discuss financial results for the second quarter of ... 2014 at 4:30 p.m. ET. Conference call ... 2014 Time: 4:30 PM ET Listen via Internet: http://ir.pharmacyclics.com/events.cfm ... A webcast replay will be available on the Pharmacyclics website ...
(Date:7/28/2014)... , July 28, 2014  Dignity Health ... has received the Get With The Guidelines®-Stroke Silver-Plus ... measures outlined by the American Heart Association/American Stroke ... is the number four cause of death and ... the United States , according to ...
(Date:7/28/2014)... Pharmaceuticals, Inc. (NASDAQ: ANTH ), today announced financial ... 30, 2014. Net loss for the three ... $8.3 million for the same period in 2013. The decrease ... in interest expense in the current period.  ... was $15.2 million, compared with net loss of $15.9 million ...
Breaking Medicine Technology:Pharmacyclics Announces Date of Conference call to discuss Financial Results for Second Quarter of 2014 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 3Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 2Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 3Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 4Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 5Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 6Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 7
Cached News: