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Enzyme complex thought to promote cancer development can also help prevent it

these silenced genes (which are believed to be oncogenes) are re-expressed. If Akt is not activated, it does not phosphorylate EZH2, and this enzyme remains bound to and methylates H3, allowing it to silence gene expression.

"Our results imply that Akt regulates the methylation activity through phosphorylation of EZH2, which may contribute to oncogenesis," Hung says.


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Contact: Nancy Jensen
nwjensen@mdanderson.org
713-794-1584
University of Texas M. D. Anderson Cancer Center
13-Oct-2005


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