Enzyme inhibitor may help lower cholesterol and unclog arteries

Atherosclerosis, the accumulation of cholesterol in the arteries that clogs the circulation and results in heart attacks and strokes, is a leading cause of death. One strategy for preventing heart disease and stroke is to clear out clogged arteries, restoring circulation. This process, known as reverse cholesterol transport is accomplished by the high-density lipoproteins (HDLs) in the blood. HDL transports excess cholesterol from the artery wall and macrophages and delivers it to the liver, where it is excreted as bile salts and cholesterol. In a study appearing in the May issue of the Journal of Clinical Investigation, Fumihiko Matsuura and colleagues from Columbia University, New York, reveal new features of this pathway that suggest an enzyme inhibitor currently in phase III clinical trials may help reduce cholesterol levels and atherosclerosis in humans.

One proposal for boosting reverse cholesterol transport has been to elevate plasma HDL levels by inhibiting a protein called CETP that transfers cholesterol esters from HDL to lower-density lipoproteins. However, there has been controversy in the medical literature as to whether CETP deficiency is pro- or anti-atherogenic. Matsuura and colleagues assessed the ability of HDL-2 from individuals deficient in CETP to promote cholesterol removal from macrophages. They observed a 23-fold increase in cholesterol efflux in these individuals compared to controls and they demonstrated that this was dependent on a molecule known as ABCG1, which is present on macrophages and contributes to the formation of HDL. They also found that the enhanced ability to promote cholesterol removal in these CETP-deficient individuals was due to increased amounts of the enzyme LCAT and apolipoprotein E in HDL-2, which allow the inner cholesterol esterrich core of HDL-2 to expand to carry greater amounts of cholesterol. In an accompanying commentary, Robert Mahley and colleagues from the University of California, San Francisco, comm

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2

Related medicine news :

1. Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
2. Enzyme triggers plaque rupture in hardened arteries, causing heart attack and stroke
3. Enzyme complex thought to promote cancer development can also help prevent it
4. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
5. COX inhibitors may weaken protective qualities of estrogen hormone therapy
6. ACE inhibitors help preserve kidney function in IgA nephropathy
7. Effectiveness of first renin inhibitor drug for treating hypertension is limited
8. Early switch to an aromatase inhibitor increases survival
9. New angiogenesis inhibitor has promise for treating deadly brain tumor
10. New report highlights aromatase inhibitor side effects
11. Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs

Post Your Comments:

(Date:6/24/2020)... ... June 24, 2020 , ... Dr. Keith ... with lip ties and tongue ties as well as sleep-disordered breathing. Recently completing ... to care with multispecialty teams including myofunctional therapists and sleep surgeons. , The ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... extremely challenging for patients and providers alike. The virus, which is primarily found ... contaminant and spreads through respiratory droplets, contact contamination, or by aerosols produced during ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... in increasing revenue for hospitals and specialty physician practices from international healthcare ... vertical payments company. , The partnership will enable Sunbelt Health Partners to ...
(Date:6/23/2020)... ... June 22, 2020 , ... ... world can now submit new construction and renovation projects in 11 categories ... (CCRC), Hospice, Independent Living, International, Renovation/Repositioning, Skilled Nursing/Post-Acute Care and Standalone Memory ...
(Date:6/23/2020)... , ... June 22, 2020 , ... ... memory impairment, has announced the Best Memory Care Facilities in Hendersonville, Tennessee. The ... features and amenities. , According to the Alzheimer’s Association, 5.6 million people ...
Breaking Medicine News(10 mins):
(Date:6/23/2020)... BETHESDA, Md. (PRWEB) , ... June 23, 2020 ... ... with DisasterReady.org to launch one of the first online COVID-19 trainings ... of the eight courses in this free training entitled COVID-19 Training for ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... of center-based, Applied Behavioral Analysis ("ABA") therapy, today announced the acquisition of ... greater-Indianapolis market. This acquisition will make Lighthouse Autism Center one of the ...
(Date:6/23/2020)... ... June 23, 2020 , ... Award-winning digital product design and ... over 60 million users, to build a COVID-19 map . The goal between ... date clarity through easy-to-understand data and visuals on the current COVID-19 situation both globally ...
Breaking Medicine Technology:
Cached News: