Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find

ll in the intraluminal pressures in the high pressure zone of the IAS tone," Dr. Rattan explains. Similarly, the ROK inhibitor caused a fall in the IAS tone in in vitro studies.

They also showed that Rho kinase was present in high levels in smooth muscle cells of the IAS. The studies demonstrated that Rho kinase inhibitors are potent smooth muscle inhibitors, causing direct smooth muscle relaxation.

"The next step in the work," says Dr. Rattan, "would be to try these kinds of tests in the hypotensive state of the IAS in animal models first, and then hopefully in humans with some of these conditions."


Contact: Steve Benowitz
Thomas Jefferson University

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