Erectile dysfunction and lower urinary tract symptoms

ANAHEIM, Ca. (May 22, 2007) -- Early research has explored a possible connection between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) and has also suggested that LUTS associated with benign prostatic hyperplasia (BPH) may be improved with phosphodiesterase (PDE) inhibitors drugs commonly prescribed for certain types of ED. The inhibition of PDE isoenzymes relaxes the smooth muscle in the prostate or bladderand can improve LUTS in BPH patients. Three studies presented during the 102nd Annual Scientific Meeting of the American Urological Association (AUA) focus on the use of PDE-5 inhibitors in treating men with co-existent LUTS and ED. A special session for media moderated by Kevin T. McVary, M.D. was held on Tuesday, May 22, 2007 at 9:00 a.m.


Data has shown a correlation between the severity of lower urinary tract symptoms (LUTS) and the severity of erectile dysfunction (ED). Researchers from the United States explored the question of whether LUTS severity can impact a patients response to ED treatment. Researchers used data from a randomized, double-blind, placebo-controlled study examining the safety and efficacy of tadalafil in men with moderate to severe benign prostatic hyperplasia (BPH) to perform this post-hoc analysis.

Of the 281 men enrolled in the study, 156 (68 percent) had a medical history of ED. Patients participated in a four-week, single-blind placebo run before being randomized to receive 5 mg tadalafil daily for six week with an increase to 20 mg daily for an additional six weeks. The control arm received placebo for the 12-week period. Patients were evaluated using the International Index of Erectile Function -- Erectile Function (IIEF EF). Scores were significantly improved in patients

Contact: Wendy Isett
American Urological Association

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