HOME >> MEDICINE >> NEWS
Estrogen, estrogen-like drugs' ability to protect brain after stroke under study

How brain cells die after a stroke and whether estrogen or estrogen-like drugs can save them is the focus of a new grant at the Medical College of Georgia.

"What we are studying is if estrogen or these estrogen-like drugs were there, would that have reduced stroke damage?" says Dr. Darrell Brann, MCG neuroscientist and principal investigator on a $1.7 million, five-year grant from the National Institute of Neurological Disorders and Stroke.

Preliminary data suggest that these substances not only help traumatized cells survive, they further enable post-stroke recovery by encouraging stem cells found in certain parts of the brain to mature into new brain cells.

The studies are in an area surrounding the core of the stroke called the penumbra, where cells might live or die in the hours and weeks following a stroke. "It's a very complex issue because what you have in a stroke is an area that is deprived of blood flow; this is usually called the ischemic core. Blood is not reaching it at all," says Dr. Brann, associate director of MCG's Institute of Neuroscience. "A lot of cell death goes on there because the cells have no nutrients coming in whatsoever. The penumbra, on the other hand, has some blood flow but it is quite diminished." And, it's a mixed blessing.

While the diminished oxygen levels enable some cells to eke by, they also enable production of free radicals, leftovers of normal metabolic processes that cause cell malfunction and death.

But oxygen alone is not to blame. Dr. Brann believes that kinases, enzymes that regulate the activity of proteins by putting phosphates on them, have an important role in the signaling cascade that causes the fragile cells to live or die. "This is a basic mechanism that is in all of us for regulation of cell signaling and to turn off different types of function. We know this process also is involved in cell death related to stroke." Dr. Brann wants to know how it's involved
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
12-Jul-2005


Page: 1 2 3

Related medicine news :

1. Study examines violations of prescription drugs black box warnings in outpatient settings
2. Post-marketing analysis examines cholesterol-lowering drugs side effects
3. Disability payments may spur drug abuse
4. International Workshop on Cities, Science and Sustainability
5. 12-month study demonstrated tolerability and efficacy of Daytrana
6. Healthy body weight throughout adulthood may help delay disability
7. Counseling, coping skills could reduce arthritis disability
8. DALYs system for measuring disability
9. Drugs for Parkinsons disease may ease stroke-related disability
10. 1 out of every 3 arthritis sufferers is affected in ability to work
11. Sustainability of energy, food and water theme of ACS national meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... The ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... 10th Anniversary of Blood Cancer Awareness Month (BCAM) and its international Light ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global ... and affordable online education – is proud to announce its new master’s degree ... of its kind in the nation, the 60-credit hour program is designed to ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang has ... with autism and other developmental disabilities, as well as supporting staff in caring ... with autism, school consultation, and staff development. She joined the company in 2015 ...
(Date:8/28/2020)... ... August 28, 2020 , ... The 15 scholarships ... Lighthouse Health & Wellness mobile app and web-portal. NCPCV received a 2020 grant ... awards grants each year to organizations, such as Destination Imagination, which support and ...
(Date:8/27/2020)... , ... August 27, 2020 , ... ... joined the Walk-in Dermatology team in its Greenvale, New York location. , ... and Skin Care Institute. She is certified in chemical peels, microdermabrasion, Hydrafacial MD, ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... September is National Ovarian Cancer Awareness ... deaths than any other cancer of the female reproductive system. The American Cancer ... and about 14,000 women will die from this disease. Throughout the month of ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... of primary care medical centers in Florida and San Antonio is happy to ... South Texas medical centers. , In this capacity he will serve as community ...
(Date:8/27/2020)... (PRWEB) , ... August 27, 2020 , ... The flu season is right round the ... get well equipped with all the necessary measures before it begins to harbor its effects ... increasing, and it is leaving a huge impact on our lives. Hence it has become ...
Breaking Medicine Technology:
Cached News: