HOME >> MEDICINE >> NEWS
Estrogen, estrogen-like drugs' ability to protect brain after stroke under study

anding the steps to cell death and how these types of drugs alter the steps, "you could design a SERM that could act on a particular tissue and have the desired effect," says Dr. Brann.

The potential of these substances to thwart the pro-death cycle seems a natural fit because estrogen and some of its metabolites have been shown in many systems to be a free-radical scavenger. Dr. Brann's preliminary studies support this, showing dramatically reduced levels of toxic superoxide, the major free radical, in stroke models treated with estrogen and tamoxifen before stroke. "We know they can do good things in other parts of the body, so what can they do to the brain?"

One additional good thing these substances may do is encourage stem cells found in the brain to rally to the stroke scene. "The old thought was that the number of neurons you have after development is all that you will ever have. The new thought is that is not exactly true," says Dr. Brann.

In fact, research has shown at least two areas of the brain have a nearby supply of stem cells that can develop into neurons and other types of brain cells.

Again, his preliminary work has shown that estrogen enhances this natural replacement process. "We can say the estrogen-treated group has more proliferation, neurogenesis is the word we use, going on in the subventricular zone of the brain four days after stroke."

Low and higher estrogen doses seem to work equally well; the jury is still out on whether tamoxifen and raloxifen can do the same. Dr. Brann is still looking at their impact and looking further at estrogen, too.

"Now what we have to do is look at two weeks, three weeks, six months. What happens? Do these new cells migrate out? Do they reach the area of infarct? We have to trace them. We have to track them. That is what the grant is about."


'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
12-Jul-2005


Page: 1 2 3

Related medicine news :

1. Study examines violations of prescription drugs black box warnings in outpatient settings
2. Post-marketing analysis examines cholesterol-lowering drugs side effects
3. Disability payments may spur drug abuse
4. International Workshop on Cities, Science and Sustainability
5. 12-month study demonstrated tolerability and efficacy of Daytrana
6. Healthy body weight throughout adulthood may help delay disability
7. Counseling, coping skills could reduce arthritis disability
8. DALYs system for measuring disability
9. Drugs for Parkinsons disease may ease stroke-related disability
10. 1 out of every 3 arthritis sufferers is affected in ability to work
11. Sustainability of energy, food and water theme of ACS national meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... , ... Dr. Jonathan Zaidan, MD, FACOG, President of Women’s Excellence discusses a ... The show airs on Wednesday, July 17ths at 7pm. The show podcast will ... Ann Thomas discuss the challenges that women face when it comes to weight loss ...
(Date:7/13/2019)... ... ... ZALO , the leading luxury sex toy manufacturer, is now shipping ... the product and its accompanying video click here . , “We are pleased ... the world,” said Mara Epstein, director of sales. “The Hero provides a unique and ...
(Date:7/13/2019)... ... July 12, 2019 , ... ... launch of its proprietary patient management platform, Ospitek “View”. Ospitek has partnered with ... to deliver a fully customizable, intelligent, solution made specifically for surgical centers, allowing ...
(Date:7/13/2019)... (PRWEB) , ... July 12, 2019 , ... ... MyBioGate and CUBIO Innovation Center , sponsored by Hangzhou Investment Promotion ... Hotel on June 2, 2019. , The conference attracted Fosun Pharmaceuticals, WuXi Biologics, ...
(Date:7/12/2019)... ... 12, 2019 , ... Fruit Street Health ( http://www.fruitstreet.com ) ... prevention program from the Centers for Disease Control and Prevention (CDC). Fruit Street ... from CDC that delivers the diabetes prevention program via telemedicine and live video ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... , ... July 17, 2019 , ... Eargo ... rapid expansion with the addition of three new executive hires: CFO Adam Laponis (from ... Engineering, Fernando Cruz (from Rappi, Inc., Apple, Inc.). , The new hires come ...
(Date:7/17/2019)... ... July 17, 2019 , ... ... DFree ®, the first wearable for urinary incontinence, will be highlighted at the ... CA, on July 26, 2019. The Innovation Showcase recognizes startups with Japanese founders ...
(Date:7/17/2019)... ... 17, 2019 , ... On July 1, 2019, Oklahoma Magazine named Whole Leaf as one of ... 20 years Oklahoma Magazine has released its Best of the Best to help readers find ... recognizes Whole Leaf for having several strains of marijuana with varying levels of THC, plus ...
Breaking Medicine Technology:
Cached News: