HOME >> MEDICINE >> NEWS
Excess oxygen worsens lung inflammation in mice

inflammatory molecules, the scientists found.

From these findings, they reasoned that oxygen therapy given to patients with acute lung inflammation might "short-circuit" this protective pathway by preventing oxygen levels from dropping enough to trigger the inflammation stop signal.

To explore this possibility in an animal model, Dr. Sitkovsky and his colleagues induced lung inflammation in three groups of mice. The first group of 15 mice did not receive any supplemental oxygen. While they sustained moderate lung damage, only two died. Another group of 15 mice with acute lung inflammation were treated with either 100 percent or 60 percent oxygen for 48 hours. These mice suffered very extensive lung damage, and 11 of 15 died. Finally, the scientists treated another 15 mice with acute lung inflammation with a combination of 100 percent oxygen and an adenosine-like drug to compensate for the oxygen-induced loss of natural adenosine. Only two mice in this group died, and exacerbation of lung inflammation by oxygen was prevented.

The investigators conclude that in this small animal model highly pure oxygen therapy without the addition of an adenosine substitute worsens pre-existing lung inflammation. "We suggest that these adenosine substitutes be evaluated for their possible usefulness in settings of acute lung inflammation due to infection or other causes, such as asthma or surgical trauma," says Dr. Sitkovsky.

Dr. Sitkovsky is now continuing his research at the newly established New England Inflammation and Tissue Protection Institute, a consortium at Northeastern University in Boston.

NIAID is a component of the National Institutes of Health, an agency of the U.S. Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bi
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
2-May-2005


Page: 1 2 3

Related medicine news :

1. Excess folate linked to increased birth of twins after in-vitro fertilisation
2. Excess television may lead to extra weight for preschoolers
3. UCLA imaging study reveals how pure oxygen harms the brain
4. Penn critical-care physicians recommend strategies when facing requests to end supplemental oxygen
5. Women on oxygen therapy for COPD more likely to die than men
6. Penn researchers use the abdomen to deliver oxygen to assist ailing lungs
7. Damage from oxygen may be one cause of Parkinsons disease
8. New sensor to provide early warning of oxygen loss to unborn children
9. Patients receiving supplemental oxygen during surgery have reduced risk of wound infection
10. Near infrared laser device can measure brain oxygen levels
11. Cold treatment protects against infant disability and death from oxygen loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... , ... March 27, 2017 , ... ... that for a second year in a row; they are the recipient of ... in the industry voted on the award at Design Connections 2017. Top A&D ...
(Date:3/27/2017)... California (PRWEB) , ... March 27, 2017 , ... The ... to its customers. First National Capital has added 10 new sales professionals over the ... its sales positions by 15 additional new hires over the course of 2017. ...
(Date:3/27/2017)... ... March 27, 2017 , ... Golden Triangle Emergency Center will ... April 3rd to commemorate the two-year anniversary of the facility. The event will ... two great years while also familiarizing themselves with the facility. , In the ...
(Date:3/26/2017)... ... March 26, 2017 , ... Local physician Dr. Justin Harper ... prestigious award honoring the top influencers on RealSelf—the most trusted online destination to ... and clinics. , In 2016, more than 82 million people visited RealSelf to ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... at the same time by providing Prehospital Trauma Life Support (PHTLS) course scholarships ... world’s premier prehospital trauma education developed in cooperation with the American College of ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... LightIntegra Technology Inc. today announced that its ... President and Chief Executive Officer effective March 13, 2017. ... Directors of LightIntegra. Paul Geyer will continue ... "This is the perfect time for Bill ... We,ve selected a very strong leader at a time ...
(Date:3/27/2017)... VANCOUVER, British Columbia, March 27, 2017  Sophiris ... "Company" or "Sophiris"), a clinical late-stage biopharmaceutical company ... with urological diseases, today reported fourth quarter and ... highlights. Key Corporate Highlights: ... for Localized Prostate Cancer. During 2016, the Company ...
(Date:3/27/2017)... , March 27, 2017   Pulmatrix, Inc . ... therapies to address serious pulmonary diseases, today announced that it ... disease, cystic fibrosis and asthma to its Scientific Advisory ... Richard B. Moss , MD, former chief ... of the Cystic Fibrosis Center at Stanford University, and ...
Breaking Medicine Technology:
Cached News: