HOME >> MEDICINE >> NEWS
Exercise slows development of Alzheimer's-like brain changes in mice, new study finds

Physical activity appears to inhibit Alzheimer's-like brain changes in mice, slowing the development of a key feature of the disease, according to a new study. The research demonstrated that long-term physical activity enhanced the learning ability of mice and decreased the level of plaque-forming beta-amyloid protein fragments--a hallmark characteristic of Alzheimer's disease (AD)--in their brains.

A number of population-based studies suggest that lifestyle interventions may help to slow the onset and progression of AD. Because of these studies, scientists are seeking to find out if and how physically or cognitively stimulating activity might delay the onset and progression of Alzheimer's disease. In this study, scientists have now shown in an animal model system that one simple behavioral intervention--exercise--could delay, or even prevent, development of AD-like pathology by decreasing beta-amyloid levels.

Results of this study, conducted by Paul A. Adlard, Ph.D., Carl W. Cotman, Ph.D., and colleagues at the University of California, Irvine, are published in the April 27, 2005, issue of The Journal of Neuroscience. The research was funded in part by the National Institute on Aging (NIA), a component of the National Institutes of Health, U.S. Department of Health and Human Services. Additional funding was provided by the Christopher Reeve Paralysis Foundation.

To directly test the possibility that exercise (in the form of voluntary running) may reduce the cognitive decline and brain pathology that characterizes AD, the study utilized a transgenic mouse model of AD rather than normal mice. The transgenic mice begin to develop AD-like amyloid plaques at around 3 months of age. Initially, young mice (6 weeks or 1 month of age) were placed in cages with or without running wheels for periods of either 1 month or 5 months, respectively. Mice with access to running wheels had the opportunity to exercise any time, while those without the wh
'"/>

Contact: Susan Farrer
301-496-1752
NIH/National Institute on Aging
26-Apr-2005


Page: 1 2 3

Related medicine news :

1. Exercise lowers insulin in breast cancer survivors
2. Exercise test may help predict mortality risk in heart failure patients
3. Exercise may slightly boost good cholesterol levels
4. Exercise may lead to improvement in patients with Parkinsons
5. Exercise can cut coronary artery disease risk for some with MS
6. Exercise science principles strengthen swallowing rehabilitation
7. Exercise improves quality of life for people with breast cancer
8. Exercise has no effect on risk of knee osteoarthritis
9. Exercise enhances seniors physical, mental functioning
10. Exercise helps elderly regain physical function and avoid major disability
11. Exercise helps breast cancer patients avoid anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2017)... ... 24, 2017 , ... In “Sky and I”, a young boy was walking home and feeling down about himself. ... him otherwise. The new friend says he can do whatever he wants to do if ... enough just the way he is. God created him with special talents and gifts. We ...
(Date:9/24/2017)... (PRWEB) , ... September 24, 2017 , ... “The Gospel Truth Of The Bible: The ... “The Gospel Truth Of The Bible: The Other Sheep” is the creation of published author, ... born in the West Indies. He has been a member of the Seventh-day Adventist ...
(Date:9/23/2017)... ... September 23, 2017 , ... Silicon Valley Hair Institute, the leading ... new blog post focused on the ARTAS® hair transplant system and the younger demographic. ... the latest, most technologically sophisticated methods of hair restoration. , “It can be emotionally ...
(Date:9/22/2017)... ... ... MEDIA OPPORTUNITY: , Save Our Hospital - Albert Lea will host media ... against Mayo Clinic. Specifically, media can talk to steering committee members and patients regarding ... the Albert Lea hospital. , The rally aims to protect the most vulnerable and ...
(Date:9/22/2017)... PA (PRWEB) , ... September 22, 2017 , ... ... soon as possible, and they often saves lives. However, if one isn’t accessible ... to widen the availability of defibrillation, I came up with this idea," said ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... -- NeuroRx, a clinical stage biopharma company developing the first ... been granted Fast Track status by the US Food and ... followed by NRX-101 (D-cycloserine + lurasidone). The company will shortly ... therapy targeting patients who are admitted to Emergency Departments with ... ...
(Date:9/5/2017)... another milestone in their continued growth and success of the company.  Xyntek has ... engagements regionally.  ... at 318 West Adams Street, Suite 1528, Chicago, IL ... Xyntek's recently opened Midwest office will support the ... In addition to Xyntek,s headquarters ...
(Date:9/5/2017)... 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company focused on the development of oral drug ... its meeting with the U.S. Food and Drug Administration ... At the meeting, ... for submission of ORMD-0801, would be a Biologics License ...
Breaking Medicine Technology:
Cached News: