HOME >> MEDICINE >> NEWS
Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

Early-stage research has found that a new gene therapy can nearly eliminate arthritis pain, and significantly reduce long-term damage to the affected joints, according to a study published today in the journal Arthritis and Rheumatism. While the study was done in mice, they are the first genetically engineered to develop osteoarthritis like humans, with the same genetic predisposition that makes some more likely to develop the disease, the authors said. If all goes well with a follow-up study currently underway, researchers will apply to the U.S. Food and Drug Administration for permission to begin human trials next year.

Nearly everyone aged 65 or older suffers from the pain, swelling and permanent joint damage of osteoarthritis. The most common form of arthritis, it develops over time following initial joint injuries or just as a result of aging. In the current study, researchers found that one injection of a newly designed gene therapy relieved 100 percent of osteoarthritic pain in the study model. In addition, researchers were surprised to find that the therapy also brought about a nearly 35 percent reduction in permanent structural to joints caused by round and after round of osteoarthritic inflammation.

To date, treatment of arthritis is dominated by drug treatments like non-steroidal, anti-inflammatory drugs, COX-2 inhibitors and acetominophen. Morphine and its derivatives are still in common use as well, but can depress breathing and lead to addiction. Taken together, current treatments deliver inconsistent results and new approaches are needed, researcher said. Gene therapy has been attempted in the past, but older, invasive techniques required that therapeutic genes be injected directly into nerve cells. Strong pain relief resulted, but in some cases the injections caused nerve damage.

"Our publication represents the first proof that gene therapy can work in a way that is clinically applicable," said Stephanos Kyrkanides, D
'"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
University of Rochester Medical Center
25-May-2007


Page: 1 2 3 4

Related medicine news :

1. Mayo Clinic research in cardiovascular disease presented at Experimental Biology 2007
2. Experimental flu vaccine appears promising in early tests
3. Experimental ragweed therapy offers allergy sufferers longer relief with fewer shots
4. Experimental medication kicks depression in hours instead of weeks
5. Experimental vaccine protects lab animals against several strains of H5N1
6. Experimental shingles vaccine proves effective in nationwide study
7. Experimental therapies and vaccines for Ebola and Marburg viruses focus of Academy meeting
8. Chemotherapy with bevacizumab increases risk of blood clots in arteries
9. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
10. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
11. Hormone therapy offers new hope for ovarian cancer patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2020)... ... , ... Sex educator, activist, humanitarian, and Wicked Pictures star jessica drake ... 2020 AASECT Audio Visual Award for jessica drake's Guide to Wicked Sex: Senior Sex. ... feature non-actors in its demonstrations and narratives and was produced and distributed by Wicked ...
(Date:5/21/2020)... ... May 21, 2020 , ... In response to the ... that allows users to open swing-style doors without using their hands or fingertips. ... to pull the door open using their forearm, wrist or elbow when entering or ...
(Date:5/21/2020)... ... May 21, 2020 , ... A Safe Haven Foundation (ASHF) has ... $5 million AbbVie COVID-19 Community Resilience Fund. The fund was created in March to ... frontline homeless workers in service to vulnerable populations in hard-hit communities. , “We ...
(Date:5/21/2020)... ... ... The Rise of Mental Health and Substance Abuse During COVID-19, Entering into this ... say, more complications. With rising deaths, more confirmed cases every day, and unemployment rates ... escape and find peace. Adding to these persistent stressors are quarantine orders. Stressors and ...
(Date:5/17/2020)... ... May 18, 2020 , ... R3 Stem Cell International ... regenerative clinic. There are two program options for patients and their families, which ... it is unclear exactly what causes Autism Spectrum Disorder (ASD), there are several ...
Breaking Medicine News(10 mins):
(Date:5/28/2020)... ... May 28, 2020 , ... ... patient-care products led M&S Technologies, leader and innovator in essential vision testing products, ... M&S Technologies ’ web-based Vision Testing has been released and considering the circumstances, ...
(Date:5/27/2020)... ... ... 2020: , CARDIOLOGY, Passaic County, Dr. Anuj Shah , CHIROPRACTIC ... Dr. Mi Jo , Morris County, Dr. Derek ... , FAMILY PRACTICE, Camden County, Dr. Krista King , ...
(Date:5/27/2020)... ... 2020 , ... Hemp Health One’s Giving Away Free CBD Supplements for the next 60 days ... The company is hosting the daily giveaway contest on its Instagram and Facebook pages. ... page or Hemp Health One’s Facebook page. Then, like the most recent post, share it, ...
Breaking Medicine Technology:
Cached News: