HOME >> MEDICINE >> NEWS
Exploring better ways to determine when to change the course of treatment

Counting circulating tumor cells before and after the start of treatment for patients with metastatic colorectal cancer could help doctors determine when or if a change in treatment should be made. The results of a large, multicenter, international study laying the groundwork for such decisions were presented today at the Annual Meeting of the American Society of Clinical Oncology. The study showed the number of circulating tumor cells, or CTC, is a significant predictor of survival and cancer progression.

Few studies have examined the relationship of CTC and a patient's prognosis in cancer. This is an important area of research in metastatic colorectal cancer because there are little data to help physicians chose which treatment is best for which patients or to determine when a change in treatment is warranted.

"If we had a way to know early on that a tumor isn't responding to a particular drug, we could switch to a different treatment before growth of the cancer is seen on a CAT scan," said Neal J. Meropol, director of the gastrointestinal cancer program at Fox Chase Cancer Center and lead investigator of the study. "If we could determine that the tumor was destined to grow after a few weeks of treatment, we'd be able alter course even before the first scan."

For this study, Meropol and his colleagues examined the association between the circulating tumor cell number and progression-free and overall survival for 430 adult patients with metastatic colorectal cancer.

The number of CTC was measured at baseline, one month, and several other points after the start of treatment. CTC were isolated and counted by an immunomagnetic cell separation technique, an FDA-approved technology developed by Immunicon Corporation (Nasdaq-Global Market: IMMC}. CT scans were obtained in usual practiceat baseline and every 6-12 weeks after starting treatment.

Having 3 or more CTC (per 7.5 mL of blood) was defined as "unfavo
'"/>

Contact: Karen Mallet
karen.mallet@fccc.edu
215-728-9751
Fox Chase Cancer Center
3-Jun-2007


Page: 1 2

Related medicine news :

1. Exploring the molecular origin of blood clot flexibility
2. Exploring the potential of cholesterol-lowering drugs for patients with systemic sclerosis
3. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
4. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
5. Warfarin better than aspirin at stroke prevention in elderly people with atrial fibrillation
6. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
7. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
8. Holograms make for better vision tests
9. Parents of chronically ill kids are helped by better access to federal and employer leave
10. Diabetes professionals join forces to identify gaps in diabetes care and better self care
11. Gene variations point to why lung cancer drugs work better in Japanese vs. US patients

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Exploring better ways determine when change the course treatment

(Date:7/28/2015)... ... 2015 , ... Carol McFarland, PT, PhD, OCS focuses entirely ... specific rehabilitation exercises and treatment protocols in the PTA OT PT Continuing ... interview conducted by Carol with a board certified neurosurgeon. Specific case studies are ...
(Date:7/28/2015)... SD (PRWEB) , ... July 28, 2015 , ... Peter Forbes, President of the Veterans ... of the Vietnam War Inc. and the Veterans Coalition, is spearheading a campaign to help ... , The UVBH teaches Veterans life and trade skills. Forbes and the UVBH assists and ...
(Date:7/27/2015)... ... July 28, 2015 , ... Conducting Advanced Root Cause Analysis ... the Quality of Investigations , **Presented by FDAnews and Learning Plus**, Sept. 16-17, ... been the #1 reason for 483 observations since 1997! , The FDA's enforcement ...
(Date:7/27/2015)... , ... July 28, 2015 , ... The National ... inductee into the NAPW VIP Woman of the Year Circle. She is recognized with ... 200 operating Local Chapters, NAPW is the nation’s leading networking organization exclusively for professional ...
(Date:7/27/2015)... ... July 27, 2015 , ... The FSH ... and incurable disease, facioscapulohumeral muscular dystrophy (FSHD), today announced the introduction of the ... FSHD care guideline is published today. , This new guideline condenses the ...
Breaking Medicine News(10 mins):Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 2Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 3Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 4Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 5Health News:North American Seminars Introduces a New OT PT PTA Online Continuing Education Course on the Treatment of Post Surgical Cervical and Lumbar Spine Patients 6Health News:Veterans Fund of the United States Launches “Adopt A Homeless Veteran” Campaign 2Health News:Veterans Fund of the United States Launches “Adopt A Homeless Veteran” Campaign 3Health News:FDAnews Announces: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 16-17, 2015, Raleigh, NC 2Health News:FDAnews Announces: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 16-17, 2015, Raleigh, NC 3Health News:FDAnews Announces: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 16-17, 2015, Raleigh, NC 4Health News:NAPW Inducts Jane Simmons, Counseling Intern at Omar Bradley Middle School of the Northeast Independent School District , Into its VIP Woman of the Year Circle 2Health News:First-Ever FSHD Evidence-based Care Guideline Published by the American Academy of Neurology 2
(Date:7/27/2015)... HERTFORDSHIRE, England and PITTSBURGH , ... today announced that it will hold its extraordinary general meeting ... Company plc (NYSE: PRGO ; TASE) at the Okura ... Central European Time (CET). Among other agenda ... to vote on the approval, under article 2:107a of the ...
(Date:7/27/2015)... , July 27, 2015  QT Vascular Ltd., ... a global company engaged in the design, assembly and ... treatment of vascular disease, has entered into an agreement ... to US$13.14 million convertible bond investment. This funding will ... its growth to the next milestone. ...
(Date:7/27/2015)... WASHINGTON , July 27, 2015 Even ... Larkin , MD, FACP, NCMP, as scientific co-chair for ... health coalition to serve as an expert voice in ... treatment options for women struggling with Hypoactive Sexual Desire ... "I am honored to join Even ...
Breaking Medicine Technology:Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 2Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 3Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 4Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 5Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 6Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 7Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 8Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 9Mylan Announces Meeting Date and Record Date of Extraordinary General Meeting of Shareholders 10QT Vascular Obtains Funding To Boost Growth Through Issuance of up to US$13.14 Million Convertible Bonds 2QT Vascular Obtains Funding To Boost Growth Through Issuance of up to US$13.14 Million Convertible Bonds 3Dr. Lisa Larkin Joins the Even the Score Coalition as Scientific Co-Chair 2Dr. Lisa Larkin Joins the Even the Score Coalition as Scientific Co-Chair 3
Cached News: