HOME >> MEDICINE >> NEWS
Exploring better ways to determine when to change the course of treatment

Counting circulating tumor cells before and after the start of treatment for patients with metastatic colorectal cancer could help doctors determine when or if a change in treatment should be made. The results of a large, multicenter, international study laying the groundwork for such decisions were presented today at the Annual Meeting of the American Society of Clinical Oncology. The study showed the number of circulating tumor cells, or CTC, is a significant predictor of survival and cancer progression.

Few studies have examined the relationship of CTC and a patient's prognosis in cancer. This is an important area of research in metastatic colorectal cancer because there are little data to help physicians chose which treatment is best for which patients or to determine when a change in treatment is warranted.

"If we had a way to know early on that a tumor isn't responding to a particular drug, we could switch to a different treatment before growth of the cancer is seen on a CAT scan," said Neal J. Meropol, director of the gastrointestinal cancer program at Fox Chase Cancer Center and lead investigator of the study. "If we could determine that the tumor was destined to grow after a few weeks of treatment, we'd be able alter course even before the first scan."

For this study, Meropol and his colleagues examined the association between the circulating tumor cell number and progression-free and overall survival for 430 adult patients with metastatic colorectal cancer.

The number of CTC was measured at baseline, one month, and several other points after the start of treatment. CTC were isolated and counted by an immunomagnetic cell separation technique, an FDA-approved technology developed by Immunicon Corporation (Nasdaq-Global Market: IMMC}. CT scans were obtained in usual practiceat baseline and every 6-12 weeks after starting treatment.

Having 3 or more CTC (per 7.5 mL of blood) was defined as "unfavo
'"/>

Contact: Karen Mallet
karen.mallet@fccc.edu
215-728-9751
Fox Chase Cancer Center
3-Jun-2007


Page: 1 2

Related medicine news :

1. Exploring the molecular origin of blood clot flexibility
2. Exploring the potential of cholesterol-lowering drugs for patients with systemic sclerosis
3. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
4. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
5. Warfarin better than aspirin at stroke prevention in elderly people with atrial fibrillation
6. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
7. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
8. Holograms make for better vision tests
9. Parents of chronically ill kids are helped by better access to federal and employer leave
10. Diabetes professionals join forces to identify gaps in diabetes care and better self care
11. Gene variations point to why lung cancer drugs work better in Japanese vs. US patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... SAN ANTONIO (PRWEB) , ... August 21, 2019 , ... ... in skin care products. This water-based ingredient is currently used in skincare products such ... with PPT. The award-winning product addresses the growing need to protect the skin from ...
(Date:8/21/2019)... ... August 21, 2019 , ... Future residents got their ... Phase II expansion of Providence Point in Pittsburgh’s Scott Township neighborhood involved additions, ... the 70-unit apartment tower, Hamilton Tower. , The expansion began two ...
(Date:8/19/2019)... MEADOWS, Ill. (PRWEB) , ... August 19, 2019 ... ... performed more than 12.5 million medically necessary and cosmetic procedures in 2018 – ... Now in its seventh year, the 2018 ASDS Survey on Dermatologic Procedures ...
(Date:8/19/2019)... , ... August 19, 2019 , ... A July 26 ... dog owners should be brushing their pets’ teeth twice a day. The acknowledges that, ... the time and suggests that close monitoring and brushing at least twice a week ...
(Date:8/17/2019)... ... August 17, 2019 , ... Approximately 50 area ... services today under a program sponsored by United Concordia Dental and Mission Arlington/Metroplex. ... work alongside them to make these services available to area youths who are ...
Breaking Medicine News(10 mins):
(Date:8/21/2019)... ... August 21, 2019 , ... Dr. Leonard Bley at ... newest laser ReLEx® SMILE (Small Incision Lenticule Extraction) located in their state-of-the-art Manhattan surgery ... SMILE in the Tri-State area. SMILE is a one-step, one laser procedure that is ...
(Date:8/21/2019)... ... 21, 2019 , ... Impact Advisors , a leading provider of clinical, ... has been named to Inc. magazine’s Inc. 5000 list. The Inc. 5000 list is ... percentage revenue growth. This year the firm was also named a 5-Time Inc. 5000 ...
(Date:8/19/2019)... (PRWEB) , ... August 18, 2019 , ... Laurence Fishburne ... all ages across the globe. His work spans genres and generations. On television, he ... a series that covers topics important to today's world and gives viewers information in ...
Breaking Medicine Technology:
Cached News: