HOME >> MEDICINE >> NEWS
Exposure to PCBs may reduce the effectiveness of vaccines in children

Boston, MA -- New epidemiological evidence suggests that exposure to environmental pollutants may have an adverse impact on immune responses to childhood vaccinations. The research appears in the Aug. 22, 2006, online edition of Public Library of Science Medicine.

The study looked at two groups of children in the Faroe Islands, which are located in the North Atlantic and where traditional diets may include whale blubber contaminated with polychlorinated biphenyls (PCBs). Blood and milk samples taken during pregnancy from the mothers were analyzed to determine the children's prenatal PCB exposure. After routine childhood vaccinations against tetanus and diphtheria, the two groups of children were examined at age 18 months and 7 years, and blood samples were examined for tetanus and diphtheria antibodies.

The findings showed an association between increased PCB contamination and lowered antibody response to the vaccines. At 18 months, the diphtheria antibody concentration decreased by 24 percent for each doubling of the PCB exposure. At 7 years, the tetanus antibody response showed the strongest response and decreased by 16 percent for each doubling of the prenatal exposure.

"Our study raises concern that exposure to PCB and similar compounds may make childhood vaccinations less efficient," said Philippe Grandjean, adjunct professor at Harvard School of Public Health and co-author of the paper. Exposed children may also be more susceptible to infections in general, he said.

There were some limitations to the study, including the relatively small numbers of children who were examined and the time intervals between collection of blood samples. PCB is present in fatty fish worldwide and is known from laboratory studies to affect the development of the immune system. The evidence that PCB exposure may have adverse effects on the immune function in children therefore suggests that vaccine effectiveness may be an additional reason
'"/>

Contact: Christina Roache
croache@hsph.harvard.edu
617-432-6052
Harvard School of Public Health
22-Aug-2006


Page: 1 2

Related medicine news :

1. Exposure to mercury preservatives before birth is no higher in children with autism
2. Exposures to the insecticide chlorpyrifos in pregnancy adversely affect child development
3. Exposure to toxins reduces the effectiveness of immunisation and more
4. Exposure to radiation after Chornobyl increases risk of thyroid cancer in children and adolescents
5. Exposure to fine particle air pollution linked with risk of respiratory and cardiovascular diseases
6. Exposure to military trauma related to post-war disease and death in Civil War veterans
7. Exposure to pesticides in schools produces illnesses among school employees and students
8. Occupational and Environmental Exposures of Skin to Chemicals-2005
9. Exposure to aircraft noise may affect childrens reading and memory
10. Exposure to carcinogenic crop toxin lowered by simple intervention
11. Trial stops after stroke and mortality significantly reduced by blood

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2020)... , ... April 04, 2020 , ... ... report conforming to the newly mandated federal reporting of COVID-19 testing that must ... March 29, 2020, Vice President Pence announced that all hospitals report data on ...
(Date:4/2/2020)... ... April 02, 2020 , ... LifeLearn Animal Health , ... announced the launch of the veterinary CE course COVID-19: What we know and ... subscribers. , “When it comes to COVID-19, it’s important for practices and pet owners ...
(Date:4/1/2020)... ... April 02, 2020 , ... ... 3:00 pm PT/6:00 pm ET- to discuss surgical safety practices in response to ... Maryland, Louisiana State University Healthcare Network in New Orleans and Amsterdam University Medical ...
(Date:4/1/2020)... Md. (PRWEB) , ... April 01, 2020 , ... ... method using its revolutionary NEXTGENPCR that decreases the testing time for SARS-CoV-2 ... method, a single unit the size of a shoebox could perform a hundred and ...
(Date:3/30/2020)... ... March 30, 2020 , ... Frontline Public Safety Solutions ... In an effort to keep frontline officers and the public safe in the ... members while minimizing direct contact. They are also freeing up 911 lines for ...
Breaking Medicine News(10 mins):
(Date:3/30/2020)... ... March 30, 2020 , ... ... critical for business continuity. Unfortunately, we hear stories from our customers of vendor ... unconscionable to take advantage of people’s hardships in this difficult time,” says Borya ...
(Date:3/30/2020)... ... March 30, 2020 , ... ... part of their business continuity and thebigword is making its neural machine translation ... thebigword will be able to use the neural machine translation tools to support ...
(Date:3/28/2020)... ... March 28, 2020 , ... TriageLogic, a leader in remote patient communication and ... a virtual call center that hospitals, medical organizations, and health centers can use for ... pandemic, they are looking for a system that can be quickly deployed for staff ...
Breaking Medicine Technology:
Cached News: