HOME >> MEDICINE >> NEWS
Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find

PHILADELPHIA - A natural substance secreted by fat cells can protect blood vessels from the damaging effects of inflammation, one of the factors that contribute to heart disease. Researchers at Jefferson Medical College have shown for the first time in an animal model that the substance a protein called adiponectin helps prevent immune system white blood cells from binding to the inside of blood vessel walls. Harnessing adiponectin's properties, the scientists suggest, may someday help protect against the blood vessel damage so prevalent in patients with obesity and diabetes.

Reporting June 1, 2007 in the Journal of Clinical Investigation, researchers led by Barry Goldstein, M.D., Ph.D., professor of medicine and director of the Division of Endocrinology, Diabetes and Metabolic Diseases and Rosario Scalia, M.D., Ph.D., associate professor of molecular physiology and biophysics, both of Jefferson Medical College of Thomas Jefferson University in Philadelphia, discovered that mice lacking adiponectin had an increase in so-called "adhesion" molecules and high levels of white blood cells sticking to the inside of blood vessel walls, which are signs of inflammation. When they gave the animals the "active" piece of the normal adiponectin molecule for 10 days, inflammation in the blood vessels was greatly reduced.

"This is translational work," says Dr. Scalia. "Weve used a mouse model to prove Adiponectin conceptually what we see in a test tube system in isolated cells is relevant to an intact physiological system. It's a necessary step before going to humans. These results suggest that perhaps restoring this protein could be important to preventing atherosclerosis and vascular disease."

They used a technique, intravital microscopy, which permits researchers to illuminate blood vessels using fluorescent signals, enabling them to see reductions in white cells on the vessel wall and subsequent lessening in inflammation.

The
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
1-Jun-2007


Page: 1 2 3

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
5. Cow protein aids in treatment of gastrointestinal disorder
6. Study implicates protein as a trigger of advanced prostate cancer recurrence
7. Speeding fingertip discovery -- 20 years of protein info in 1 place
8. Head and neck cancer vaccine targets proteins to create immune response
9. Slick and springy: Brown research reveals proteins role in joints
10. Blocking immune cell action increases Alzheimers-associated protein deposits
11. U of M discovers protein linked to elevated BMI in people of American Indian and Mexican ancestry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2019)... Calif. (PRWEB) , ... April 19, 2019 , ... According ... the United States alone comes with pesticide residue. Pesticides are sprayed on produce to ... and soils are what make up that thin, waxy layer that covers the skin ...
(Date:4/19/2019)... , ... April 18, 2019 , ... Residents in long-term-care ... by outside physicians. This is according to a study of U.S. men ... the auspices of the Brandman Research Institute (BRI) . The quality assurance study ...
(Date:4/18/2019)... ... 18, 2019 , ... Catalent, a global leader in clinical ... Clinical Supplies Group (GCSG) 2019 US Annual Conference at the Hyatt Regency Hill ... 2019. , Erin Vlack, Project Manager, will present a workshop titled “Bridging the ...
(Date:4/18/2019)... MONTPELIER, Vt. (PRWEB) , ... April 18, 2019 ... ... strengthening Vermont’s captive regulation in a variety of areas. This year’s bill proposed ... schedule and improvements to the statute governing group captive investments. The many enhancements ...
(Date:4/18/2019)... ... April 18, 2019 , ... WHAT:, ... for their care. Through the rise of online review sites and healthcare-related searches ... and transparency when making important purchasing decisions online. In order to elevate a ...
Breaking Medicine News(10 mins):
(Date:4/18/2019)... ... April 18, 2019 , ... Global Lyme Alliance (GLA), the ... and awareness, and Ranger Ready Repellents, a new EPA-registered brand of body-worn ... prevention, including the proper use of repellents, to safeguard the public from tick ...
(Date:4/17/2019)... ... April 17, 2019 , ... As an employer do you feel overwhelmed by all of the ... to use? How can you best engage your employees? Do you have the budget for ... Join benefits administration experts Mike Ehrle, SVP of Strategic Partnerships, Hodges-Mace and Jay ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... Allegheny Health Network (AHN) and Gateway Health have launched a new program that ... life. , AHN’s Enhanced Pain Management Program brings together a range of ...
Breaking Medicine Technology:
Cached News: