HOME >> MEDICINE >> NEWS
Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find

PHILADELPHIA - A natural substance secreted by fat cells can protect blood vessels from the damaging effects of inflammation, one of the factors that contribute to heart disease. Researchers at Jefferson Medical College have shown for the first time in an animal model that the substance a protein called adiponectin helps prevent immune system white blood cells from binding to the inside of blood vessel walls. Harnessing adiponectin's properties, the scientists suggest, may someday help protect against the blood vessel damage so prevalent in patients with obesity and diabetes.

Reporting June 1, 2007 in the Journal of Clinical Investigation, researchers led by Barry Goldstein, M.D., Ph.D., professor of medicine and director of the Division of Endocrinology, Diabetes and Metabolic Diseases and Rosario Scalia, M.D., Ph.D., associate professor of molecular physiology and biophysics, both of Jefferson Medical College of Thomas Jefferson University in Philadelphia, discovered that mice lacking adiponectin had an increase in so-called "adhesion" molecules and high levels of white blood cells sticking to the inside of blood vessel walls, which are signs of inflammation. When they gave the animals the "active" piece of the normal adiponectin molecule for 10 days, inflammation in the blood vessels was greatly reduced.

"This is translational work," says Dr. Scalia. "Weve used a mouse model to prove Adiponectin conceptually what we see in a test tube system in isolated cells is relevant to an intact physiological system. It's a necessary step before going to humans. These results suggest that perhaps restoring this protein could be important to preventing atherosclerosis and vascular disease."

They used a technique, intravital microscopy, which permits researchers to illuminate blood vessels using fluorescent signals, enabling them to see reductions in white cells on the vessel wall and subsequent lessening in inflammation.

The
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
1-Jun-2007


Page: 1 2 3

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. Blocking stress protein decreases Alzheimers peptide in mice
4. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
5. Cow protein aids in treatment of gastrointestinal disorder
6. Study implicates protein as a trigger of advanced prostate cancer recurrence
7. Speeding fingertip discovery -- 20 years of protein info in 1 place
8. Head and neck cancer vaccine targets proteins to create immune response
9. Slick and springy: Brown research reveals proteins role in joints
10. Blocking immune cell action increases Alzheimers-associated protein deposits
11. U of M discovers protein linked to elevated BMI in people of American Indian and Mexican ancestry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/14/2018)... ... December 14, 2018 , ... Our competitor ... has pending lawsuits that claim its talc powder has toxic ingredients that may ... asbestos in its baby powder. The documents also show our competitor's leadership intentionally ...
(Date:12/14/2018)... Calif. (PRWEB) , ... December 14, 2018 , ... Art ... Art of Dentistry, are helping patients in La Mesa, CA interested in cosmetic dentistry ... for individuals whose teeth and gums are not aesthetically appealing because of decay, damage, ...
(Date:12/13/2018)... ... December 13, 2018 , ... Cantata Health, a leading ... outcomes, introduced new enhancements to its NetSolutions™ platform. The new features and partnerships ... technology and screen time. , Enhancements made to EHR and Financial Management ...
(Date:12/13/2018)... ... 13, 2018 , ... New research out of Roswell Park Comprehensive Cancer Center ... significantly more likely to survive than those who are sedentary, adding to the growing ... and treatment strategy. The results were published in a recent issue of the journal ...
(Date:12/13/2018)... Wis. (PRWEB) , ... December 13, 2018 , ... ... as Senior Vice President of Consultant Engagement. Beth brings over 20 years of ... team at Evergreen. Beth is passionate about building strong teams and creating vibrant ...
Breaking Medicine News(10 mins):
(Date:12/13/2018)... , ... December 13, 2018 , ... ... has joined the esteemed Haute Beauty network. , The Haute Beauty Network, ... Dr. Lessner as a leading vision expert and our newest addition to the ...
(Date:12/13/2018)... ... December 13, 2018 , ... The American Board ... to announce a partnership to award Continuing Medical Education (CME/SAM) credits to participants ... has selected ASCP, a leading educational provider for pathologists, as the accredited ACCME ...
(Date:12/13/2018)... ... December 13, 2018 , ... As the ... and established organizations, as well as top talent, have the ability to remain ... them. , Through years of working hand-in-hand with some of the country’s ...
Breaking Medicine Technology:
Cached News: