HOME >> MEDICINE >> NEWS
Fatal brain disease holds clues to dementia

Scientists at Melbourne's Howard Florey Institute have uncovered a clue about the causes of dementia in Huntington's disease, one of the disease's symptoms, by showing that mice susceptible to Huntington's disease have problems with learning and memory before the diseases' typical movement problems appear.

The Florey scientists also discovered that in Huntington's diseased brains, information processing between neurons is disrupted, but the neurons do not die, which means the brain may respond to new anti-dementia drugs that can restore memory.

Huntington's disease is an incurable, inherited disorder of the nervous system that affects specific brain regions and inevitably leads to death. Symptoms range from disrupted control of movements and thought processes, and emotional problems. These include: jerky arm or leg movements; difficulties with speech, swallowing, concentration, memory and learning; and depression and personality changes.

Huntington's disease is caused by a mutation in a single gene. When this defective gene is passed from parent to child, 50 percent of the offspring will inherit the disorder, which can be detected by genetic testing.

Research leader Dr Anthony Hannan said his team's investigations were significant as they could lead to the development of memory restoring drugs designed especially for people with Huntington's disease.

"We have demonstrated the linkage from molecule to cell to learning and memory, and can relate this to a particular area of the brain," Dr Hannan said.

"Our work shows that the defective huntingtin gene disrupts how large groups of neurons 'talk' to one another and adjust their wiring in response to stimulation from the environment."

"Now we can better understand how a genetic change affects wiring of neurons and relate that to changes in learning, memory and behaviour in Huntington's disease."

"By better understanding the disease mechanism, we can work
'"/>

Contact: Merrin Rafferty
m.rafferty@hfi.unimelb.edu.au
61-38-344-1658
Research Australia
26-Apr-2005


Page: 1 2 3

Related medicine news :

1. Fatalistic beliefs about cancer cause many to ignore cancer prevention advice
2. Draining away brains toxic protein to stop Alzheimers
3. New research discovers independent brain networks control human walking
4. ADHD appears to be associated with depressed dopamine activity in the brain
5. First of its kind report on how children with brain tumors perform at school
6. Chemical in brain acts like a fuel gauge
7. Case study: cross-cultural bioethics training program helps fight African brain drain
8. Paying taxes, according to the brain, can bring satisfaction
9. Childrens brain responses predict impact of sleep loss on attention
10. Old memory traces in brain may trigger chronic pain
11. Stanford researchers track human stem cells transplanted into rat brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... ... April 25, 2017 , ... Bellus Medical, ... the first in a new class of photodynamic cosmetics (PDC). , Allumera® is ... visibly reduce outward signs of aging, and minimize the appearance of pores – ...
(Date:4/25/2017)... ... April 25, 2017 , ... As President Trump challenges ... for how his administration could impact the employee benefits industry. James Slotnick, AVP, ... most likely to make it through Congress. His discussion will focus on the ...
(Date:4/25/2017)... ... April 25, 2017 , ... As ... contracted partners to help with process innovation in drug formulation and manufacturing. ... along with state-of-the-art analytical equipment in support of their development and manufacturing goals. ...
(Date:4/25/2017)... Clara, CA (PRWEB) , ... April 25, 2017 ... ... announces the addition of predictive analytics to its patient care management module. Using ... compliance even before a patient has been initiated on continuous positive airway pressure ...
(Date:4/24/2017)... , ... April 24, 2017 , ... Emmanuel College ... busy nursing professionals advance their careers. Beginning in the fall of 2017, Emmanuel’s program ... degree in as few as 16 months and for as little as $14,528. These ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  Cogentix Medical, Inc. (NASDAQ: CGNT), ... the Urology, Uro/Gyn and Gynecology markets with innovative ... has joined the Company as Senior Vice President, ... position, Mr. Keswani will report directly to ... "Our organization is delighted that Ash has joined ...
(Date:4/20/2017)... , April 20, 2017 Research and ... Technologies - Innovation Driven by Rapidly Expanding Injectables Market and Increasing ... their offering. ... for drug delivery technologies will rise from USD 20 Billion in ... Global Drug Delivery Technologies - Innovation Driven by Rapidly Expanding ...
(Date:4/20/2017)... , April 20, 2017 Eyevensys, ... the first non-viral gene expression technology that enables the ... eye to address a wide range of ophthalmic diseases, ... and Healthcare products Regulatory Agency (MHRA) to advance its ... ...
Breaking Medicine Technology:
Cached News: