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Fellowship funds major research project on medulloblastoma

of brain tumours.

"This grant recognises the importance of Dr Thomas's current and future work on a childhood cancer that continues to claim young lives. The resources provided by the Cure for Life FoundationTM will enable us to launch a comprehensive, multifaceted research project on medulloblastoma that has the potential to make advances in treating and possibly preventing this disease," said Prof Michelle Haber, Executive Director, CCIA.

Research Goals

  • To have a better understanding of how events prior to birth and early childhood can contribute to the emergence of cancer by;

  • Identifying the mechanisms that cause specific cells, known as granule cell progenitors, (GCPs) in an embryo to persist as pre-cancerous tissue;

  • To undertake groundwork on the development of strategies to prevent nervous system cancers before they emerge

  • by identifying factors which are necessary for brain tumour initiation.

  • To distinguish between factors that initiate cancer and factors that perpetuate it;

  • To use laboratory models of medulloblastoma to elucidate how disruption of an important protein, known as the sonic hedgehog signalling protein, is linked to the development of both child and adult brain tumours;

  • To identify the target genes, including the oncogene MYCN, that may contribute to the formation of brain tumours;

  • To improve the treatment of medulloblastoma by developing new therapeutic strategies utilising novel small molecules which may inhibit the proliferation of the tumour.


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  • Contact: Susan Bogle
    SBogle@ccia.org.au
    61-2-9382-0047
    Research Australia
    3-Oct-2005


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