'Fickle' enzyme helps protect, but also can promote heart failure, animal study shows

ar study came from the National Institutes of Health (NIH), the American Heart Association, the Peter Belfer Laboratory Foundation, the American Physiological Society and the Bernard Family Foundation.

The lead Hopkins researchers who took part in this study were Eiki Takimoto, M.D., Ph.D.; Hunter Champion, M.D., Ph.D.; and Maxiang Li, M.D., Ph.D. Other Hopkins researchers who took part were Shuxun Ren, M.D.; E. Rene Rodriguez, M.D.; Nazareno Paolocci, Ph.D.; Kathleen Gabrielson, D.V.M., Ph.D.; and Yibin Wang, Ph.D. Other researchers included Barbara Tavazzi, Ph.D., University of Rome, Italy; and Giuseppe Lazzarino, Ph.D., University of Catania, Italy. Senior study author Kass is also the Abraham and Virginia Weiss Professor of Cardiology at Hopkins.

Research to date is limited on BH4, but the cofactor is being used as a treatment for phenylketonuria, a rare genetic disorder in children that results from a deficiency in the enzyme phenylalanine hydroxylase. Loss of this enzyme can lead to mental retardation, organ damage and unusual posture.

Cardiac hypertrophy commonly develops from high blood pressure, which forces the heart to pump harder to circulate blood throughout the body. According to the latest statistics from the American Heart Association, in 2002, 65 million Americans have high blood pressure (defined as systolic pressure of 140 millimeters of mercury or greater, and/or a diastolic pressure of 90 millimeters of mercury or greater, taking antihypertensive medication or being told at least twice by a physician or other health professional that they have high blood pressure). Patients who develop hypertrophy have two to three times the risk of suffering cardiovascular disease, including heart failure and sudden cardiac death.


Contact: David March
Johns Hopkins Medical Institutions

Page: 1 2 3

Related medicine news :

1. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
2. Scientists develop method to track immune system enzyme in live animals
3. Coenzyme Q10 does not improve Parkinsons disease symptoms
4. Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
5. New class of HIV drug attacks previously untargeted enzyme
6. Biologists learn structure of enzyme needed to power molecular motor
7. Scientists stop colon cancer growth in mice by blocking just one enzyme
8. Researchers probe enzyme that may lead to new SARS drugs
9. Study broadens understanding of enzymes linked to tumor promoting molecule
10. Measuring certain enzyme activity in urine shows promise for detection of bladder cancer
11. Elevated GGT enzyme may predict risk of death from cardiovascular disease

Post Your Comments:

(Date:11/26/2015)... ... 2015 , ... The Catalent Applied Drug Delivery Institute today ... dose form selection in early phase drug development. The first of these is ... together the UK’s emerging life sciences companies, corporate partners, and investors, at Milton ...
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is updating ... our surgeons performed their 6,000th free flap breast reconstruction surgery! , “What an accomplishment ... day excited to rebuild lives and it’s an honor to have served all of ...
(Date:11/26/2015)... ... 26, 2015 , ... Pixel Film Studios brings Final Cut ... Vintage. This newly styled ProTrailer pack comes with 30 all-new vintage-inspired designs, with ... users limitless opportunities to stylize and create designs quickly and easily, all within ...
(Date:11/26/2015)... , ... November 26, 2015 , ... Indosoft Inc., developer ... of an application server to improve system efficiency and reliability. , The new Q-Suite ... of these standards, the system avoids locking itself into a specific piece of software ...
(Date:11/25/2015)... ... November 25, 2015 , ... As part of a global ... attracts volunteers together who want to combine talents and resources to help create ... the process. The non-profit launched its first major fundraiser on November 6, 2015 ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... addition of the "2016 Future Horizons ... of Abuse Testing Market: Supplier Shares, Country ... report to their offering. --> ... the "2016 Future Horizons and Growth ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Drug Monitoring (TDM) Market: Supplier Shares, ... Opportunities"  report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Italian therapeutic drug monitoring market, including emerging ...
Breaking Medicine Technology:
Cached News: