HOME >> MEDICINE >> NEWS
Findings relate aspirin-induced ulcers, hearing loss

HOUSTON, Sept. 19, 2005 -- It's well known that high doses of aspirin can cause ulcers and temporary deafness, but the biochemical mechanism responsible for these phenomena has never been deciphered. New research from Rice University offers clues, showing for the first time how salicylate -- an active metabolite of aspirin -- weakens lipid membranes. Researchers believe these mechanical changes disrupt the lining of the stomach, which functions to protect underlying tissue from the acidic contents of the gut. By a similar mechanism, the changes may result in aspirin-related deafness by interfering with the proper function of prestin, a transmembrane protein that's critical for mammalian hearing.

The study appears in the September issue of Biophysical Journal.

"Our studies found that membranes exposed to physiological concentrations of salicylate were thinner, more permeable, easier to bend and more likely to rupture," said study co-author Robert Raphael, the T.N. Law Assistant Professor of Bioengineering.

All cells are surrounded by membranes, ultrathin barriers of fatty acids that are just a few nanometers thick. Membranes act like a skin, sealing off the inner machinery of the cell from the outside world. About 40 percent of human proteins are "transmembrane" proteins, molecules that stick through the membrane like a needle through a cloth.

First identified five years ago, prestin is a transmembrane protein found in the inner ear. A motor protein, prestin is thought to act like a piezocrystal, converting electrical signals into mechanical motion. In the outer hair cells of the cochlea, prestin acts as a molecular motor, causing the cells to move rhythmically and amplify the sounds we hear.

"If you change the mechanical properties of the membrane, you will likely affect the biophysical processes that take place there, including those that are mediated by membrane proteins like prestin," Raphael said.

Raphael's finding
'"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
19-Sep-2005


Page: 1 2

Related medicine news :

1. Hurricane Katrina Community Aadvisory Group Survey Findings
2. Findings on obesity among preschoolers, post partum depression among Hispanic women and more
3. Painting a Clear Picture What Do The New Womens Health Initiative Findings Mean for Women?
4. Findings advance use of adult stem cells for replacement bone
5. Findings of new Gallup survey on sleep in older adults to be released
6. Findings about anti-cancer agent could make it more effective
7. Not all drug-related deaths are drug-related
8. Heat-related deaths in middle, high school football players spikes in 2006
9. Sleep-related breathing disorder common among aggressive, bullying schoolchildren
10. Students with medical-related majors more likely to have poor quality sleep
11. Loss of stem cells correlates with premature aging in animal study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... 03, 2020 , ... MemoryCare.com, a comprehensive resource for caregivers ... Facilities in Louisville, KY. The guide identifies 17 memory care communities based on ... Alzheimer’s Association , 5.6 million people age 65 and older are living ...
(Date:9/2/2020)... ... September 02, 2020 , ... RAM Technologies, ... administering Medicare Advantage and Special Needs plans, is proud to support the 2020 ... Plans (AHIP). RAM is supporting the event as a sponsor and exhibitor and ...
(Date:9/1/2020)... ... , ... KitoTech Medical, a Seattle-based medical device company, announced ... used to accelerate the commercialization of its microMend® family of wound closure products. ... expand its customer base of healthcare systems as well as independent hospitals and ...
(Date:9/1/2020)... ... September 01, 2020 , ... As fall and winter swiftly ... Cohn Health Institute has taken this time to expand and grow into a ... Anniversary, the Cohn Health Institute will be relaunching its brand new website, expanding its ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic surgeons at Allegheny ... from Carnegie Mellon University (CMU) to develop a new heart monitoring device designed ... heart surgery. , The AGH/CMU team was recently awarded a “Trailblazer” grant from ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... ... While coronavirus cases continue to increase across the country, blood drives are ... Because about 80% of blood donations are made at drives hosted by these groups, ... hosts to ensure blood products are readily available for patients. , Those interested ...
(Date:9/1/2020)... ... September 01, 2020 , ... September is National Ovarian Cancer Awareness Month. ... any other cancer of the female reproductive system. The American Cancer Society estimates ... 14,000 women will die from this disease. Throughout the month of September, Women’s ...
(Date:8/31/2020)... ... 31, 2020 , ... If you live in New York City you will always pay more ... it’s the law of supply and demand, but are plastic surgeons in New York worth ... of their patients that make the four-hour trip to have expert aesthetic treatments by some ...
Breaking Medicine Technology:
Cached News: