HOME >> MEDICINE >> NEWS
First diagnostic indicator for Amytrophic Lateral Sclerosis (ALS) identified

Claire Collier went to see her doctor shortly after she started experiencing cramping and other symptoms. This started a series of referrals and seemingly endless stream of tests. Finally, nine months later after test after test had come back negative, she received the diagnosis of ALS. Only then could she begin to receive the treatment needed to treat her symptoms.

There was not then and is not now a simple test that can tell a patient whether or not they have ALS. But a study published in this month's issue of Neurology may change that.

Researchers from Mount Sinai School of Medicine identified three proteins that are found in significantly lower concentration in the cerebral spinal fluid of patients with ALS than in healthy individuals. These are the first biomarkers for this disease.

"ALS is a very difficult disease to diagnose. To date, there is no one test or procedure to ultimately establish the diagnosis of ALS. It is through a clinical examination and series of diagnostic tests, often ruling out other diseases," website of the ALS Association.

Giulio Pasinetti, MD, PhD, Professor of Psychiatry, Neuroscience, and Geriatrics and Adult Development, Mount Sinai School of Medicine and colleagues compared cerebral spinal fluid from patients diagnosed with ALS, patients with other neurological disorders, and healthy individuals. They found that fluid from patients with ALS had significantly lower concentrations of three proteins than either of the other groups. Evaluating the levels of these three proteins proved 95% accurate for diagnosing ALS.

The researchers found that the changes in concentration of these proteins were evident within 1.5 years of onset of symptoms. With current methods, the average time from onset of symptoms to diagnosis is two years. Testing for these protein concentrations may provide a means of early diagnosis, allowing patients to receive relief from symptoms years earlier.

"For the first
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
22-Feb-2006


Page: 1 2

Related medicine news :

1. First of its kind report on how children with brain tumors perform at school
2. First clinical trial of gene therapy for childhood blindness
3. First nationwide child health and air pollution study commences
4. First step in developing heart hormone-based pill to control high blood pressure
5. First greenhouse gas animations produced using Envisat SCIAMACHY data
6. First ozone and nitrogen dioxide measurements from MetOp-A
7. First-degree fetal heart block may be reversible
8. 10 outstanding scientists chosen as First Environmental Health Science Fellows
9. First-time mothers at increased risk for postpartum mental disorders
10. Transforming knowledge into economic benefits -- EPSRCs First Knowledge Transfer Challenge Awards
11. First Quantum Grant to fund stem cell repair of damage from stroke

Post Your Comments:
(Date:3/30/2015)... (PRWEB) March 30, 2015 “ iCareTech ” ... Report, which takes a look at the latest and coolest ... NewsWatch special reporter and technology expert, conducted the review and ... band that’s dedicated to the medical and health fields. , ... of conversation over the past couple of years. Well, at ...
(Date:3/30/2015)... On March 11, 2015, Elle Magazine, in an article ... new treatment options for dealing with stubborn, unwanted fat. Two ... product. The other three technologies use devices to deliver ultrasound ... cold ( CoolSculpting ) to kill fat cells. (see: goo.gl/NmaB4q) ... to permanently remove unwanted fat," says Dr. Simon Ourian, Medical ...
(Date:3/30/2015)... March 30, 2015 Healthy, radiant skin ... Pharmacy. The staff of pharmacists is specially trained and ... like acne, eczema and other conditions. , Most people ... patient’s dermatologist and/or PCP to tackle most skin conditions ... Pharmacy has employed specialty-trained pharmacists who have experience in ...
(Date:3/30/2015)... Innovaacom, a leading provider of medical ... it is expanding its services into Asia in 2015. ... the world comes at a time when Asia’s strengthening ... better healthcare. A rapidly growing aging population and changing ... in medicine in Asia. “We are excited to be ...
(Date:3/30/2015)... York, NY (PRWEB) March 30, 2015 ... and other neurological diseases plays an important role in ... led by scientists from the Icahn School of Medicine ... , Neurological diseases have long been associated with inflammation, ... that occurs when immune cells home in to attack ...
Breaking Medicine News(10 mins):Health News:World’s First Medical Intelligent Band was Featured on NewsWatch Television on January 30, 2015 2Health News:UltraShape and CoolSculpting: Two New Fat-Busting Technologies 2Health News:MedX Pharmacy Offers Skin Care Tips 2Health News:Innovaacom Expands Services and Medical Education Programs into Asia 2Health News:Mount Sinai Scientists Establish Link Between Neurodegenerative Disease and the Body’s Response to Viral Infection 2Health News:Mount Sinai Scientists Establish Link Between Neurodegenerative Disease and the Body’s Response to Viral Infection 3
(Date:3/30/2015)... 2015  EP Global Communications, Inc. (OTC-PINK: EPGL) In ... opened negotiations with CooperVision, Inc. at $1.1 billion ... ophthalmic technologies. As previously disclosed publicly, CooperVision, Inc. ... contact lens technologies, which has led to several ... industry experts that just one of these newly ...
(Date:3/30/2015)... AUSTIN, Texas , March 30, 2015 ... highlight the My Diabetes Emergency Plan at the 2015 ... encourage you to be prepared to manage your #diabetes ... of Endocrinology (ACE) – the charitable, educational and scientific ... – has joined forces with Lilly Diabetes to share ...
(Date:3/30/2015)... DUBLIN , Mar. 26, 2015 Research ... announced the addition of the "Computer Aided ... report to their offering. Annual estimates ... through 2020. Also, a six-year historic analysis is ... are derived from primary and secondary research. Company ...
Breaking Medicine Technology:CooperVision, Inc. Seeks Intermediary as EP Global Communications, Inc., Opens Negotiations at $1.1B 2CooperVision, Inc. Seeks Intermediary as EP Global Communications, Inc., Opens Negotiations at $1.1B 3Preparation Is Personal for Those with Chronic Illnesses 2Preparation Is Personal for Those with Chronic Illnesses 3Preparation Is Personal for Those with Chronic Illnesses 4Computer Aided Detection (CAD) - Global Strategic Business Report 2015-2020: Rising Incidence of Cancer - A Major Market Driver 2Computer Aided Detection (CAD) - Global Strategic Business Report 2015-2020: Rising Incidence of Cancer - A Major Market Driver 3Computer Aided Detection (CAD) - Global Strategic Business Report 2015-2020: Rising Incidence of Cancer - A Major Market Driver 4
Cached News: