HOME >> MEDICINE >> NEWS
First diagnostic indicator for Amytrophic Lateral Sclerosis (ALS) identified

Claire Collier went to see her doctor shortly after she started experiencing cramping and other symptoms. This started a series of referrals and seemingly endless stream of tests. Finally, nine months later after test after test had come back negative, she received the diagnosis of ALS. Only then could she begin to receive the treatment needed to treat her symptoms.

There was not then and is not now a simple test that can tell a patient whether or not they have ALS. But a study published in this month's issue of Neurology may change that.

Researchers from Mount Sinai School of Medicine identified three proteins that are found in significantly lower concentration in the cerebral spinal fluid of patients with ALS than in healthy individuals. These are the first biomarkers for this disease.

"ALS is a very difficult disease to diagnose. To date, there is no one test or procedure to ultimately establish the diagnosis of ALS. It is through a clinical examination and series of diagnostic tests, often ruling out other diseases," website of the ALS Association.

Giulio Pasinetti, MD, PhD, Professor of Psychiatry, Neuroscience, and Geriatrics and Adult Development, Mount Sinai School of Medicine and colleagues compared cerebral spinal fluid from patients diagnosed with ALS, patients with other neurological disorders, and healthy individuals. They found that fluid from patients with ALS had significantly lower concentrations of three proteins than either of the other groups. Evaluating the levels of these three proteins proved 95% accurate for diagnosing ALS.

The researchers found that the changes in concentration of these proteins were evident within 1.5 years of onset of symptoms. With current methods, the average time from onset of symptoms to diagnosis is two years. Testing for these protein concentrations may provide a means of early diagnosis, allowing patients to receive relief from symptoms years earlier.

"For the first
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
22-Feb-2006


Page: 1 2

Related medicine news :

1. First of its kind report on how children with brain tumors perform at school
2. First clinical trial of gene therapy for childhood blindness
3. First nationwide child health and air pollution study commences
4. First step in developing heart hormone-based pill to control high blood pressure
5. First greenhouse gas animations produced using Envisat SCIAMACHY data
6. First ozone and nitrogen dioxide measurements from MetOp-A
7. First-degree fetal heart block may be reversible
8. 10 outstanding scientists chosen as First Environmental Health Science Fellows
9. First-time mothers at increased risk for postpartum mental disorders
10. Transforming knowledge into economic benefits -- EPSRCs First Knowledge Transfer Challenge Awards
11. First Quantum Grant to fund stem cell repair of damage from stroke

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/22/2017)... New Freedom, PA (PRWEB) , ... April 22, ... ... of healthcare experience to his role as Vice President of Sales and Business ... direction of key GPO/IDN business partner engagements, business development, and strategic planning for ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... finds that youth violence is declining—and at noteworthy rates. Between 2002 and 2014, ... young people involved in violence in the United States. The study, Trends ...
(Date:4/21/2017)... PA (PRWEB) , ... April 21, 2017 , ... Dudnyk ... new identity emphasizes the agency’s conviction that the full potential of specialty and orphan ... are equally appreciated and aligned. , “The Unifying Effect is at the heart ...
(Date:4/21/2017)... ... April 21, 2017 , ... Crossover ... O2X , an active lifestyle company that provides Human Performance Training and ... firefighters, police offers, first responders, military officers and others in service through the ...
(Date:4/21/2017)... ... April 21, 2017 , ... Metrasens is honoured to ... the UK’s most prestigious award for business success. The company has been ... and has grown by a total of 400% over the last six years. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Vanderbilt University Medical ... patients in Nashville , Tennesse have ... Esophageal Sphincter Stimulation for GERD (LESS GERD) trial. The ... provide long-term reflux control by restoring normal function to ... 65 million people in the United States ...
(Date:4/19/2017)... 2017 Companion animal ... in pets such as canine, avian and feline. ... types such as Attenuated Live Vaccines, Conjugate Vaccines, ... and Recombinant Vaccines. Attenuated live vaccines are derived ... which have been weakend under laboratory conditions. Conjugate ...
(Date:4/19/2017)... THOUSAND OAKS, Calif. , April 19, 2017 ... premium industrial buildings it is developing at Conejo ... California , to Atara Biotherapeutics, Inc. ... patients with severe and life-threatening diseases that have ... focus on allogeneic T-cell therapies for cancer, autoimmune ...
Breaking Medicine Technology:
Cached News: