HOME >> MEDICINE >> NEWS
First diagnostic indicator for Amytrophic Lateral Sclerosis (ALS) identified

Claire Collier went to see her doctor shortly after she started experiencing cramping and other symptoms. This started a series of referrals and seemingly endless stream of tests. Finally, nine months later after test after test had come back negative, she received the diagnosis of ALS. Only then could she begin to receive the treatment needed to treat her symptoms.

There was not then and is not now a simple test that can tell a patient whether or not they have ALS. But a study published in this month's issue of Neurology may change that.

Researchers from Mount Sinai School of Medicine identified three proteins that are found in significantly lower concentration in the cerebral spinal fluid of patients with ALS than in healthy individuals. These are the first biomarkers for this disease.

"ALS is a very difficult disease to diagnose. To date, there is no one test or procedure to ultimately establish the diagnosis of ALS. It is through a clinical examination and series of diagnostic tests, often ruling out other diseases," website of the ALS Association.

Giulio Pasinetti, MD, PhD, Professor of Psychiatry, Neuroscience, and Geriatrics and Adult Development, Mount Sinai School of Medicine and colleagues compared cerebral spinal fluid from patients diagnosed with ALS, patients with other neurological disorders, and healthy individuals. They found that fluid from patients with ALS had significantly lower concentrations of three proteins than either of the other groups. Evaluating the levels of these three proteins proved 95% accurate for diagnosing ALS.

The researchers found that the changes in concentration of these proteins were evident within 1.5 years of onset of symptoms. With current methods, the average time from onset of symptoms to diagnosis is two years. Testing for these protein concentrations may provide a means of early diagnosis, allowing patients to receive relief from symptoms years earlier.

"For the first
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
22-Feb-2006


Page: 1 2

Related medicine news :

1. First of its kind report on how children with brain tumors perform at school
2. First clinical trial of gene therapy for childhood blindness
3. First nationwide child health and air pollution study commences
4. First step in developing heart hormone-based pill to control high blood pressure
5. First greenhouse gas animations produced using Envisat SCIAMACHY data
6. First ozone and nitrogen dioxide measurements from MetOp-A
7. First-degree fetal heart block may be reversible
8. 10 outstanding scientists chosen as First Environmental Health Science Fellows
9. First-time mothers at increased risk for postpartum mental disorders
10. Transforming knowledge into economic benefits -- EPSRCs First Knowledge Transfer Challenge Awards
11. First Quantum Grant to fund stem cell repair of damage from stroke

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... (PRWEB) , ... September 03, 2020 , ... ... in radiology will be the focus of Fall 2020 Virtual Conference, a two-day ... , "AI, Enterprise Imaging & Beyond" is the follow-up to AuntMinnie.com's successful ...
(Date:9/1/2020)... Calif. (PRWEB) , ... September 01, 2020 , ... ... a new practice in Glendale. While the office will be the ... as breast augmentation, tummy tucks, buttock augmentation (Brazilian butt lift), as well as ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic ... joining biomedical engineers from Carnegie Mellon University (CMU) to develop a new heart ... have undergone open heart surgery. , The AGH/CMU team was recently awarded a ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... cloud-based business management solution for chiropractors, announced today the launch of its integrated, ... professionals can start running their virtual practice in under 90 seconds. , ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to ... is donating 10 percent of each hotel room booked with a special new ... Chicagoland & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be applied to ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... ... New York City you will always pay more for these two things: real estate and ... but are plastic surgeons in New York worth the premium prices that they charge? ... trip to have expert aesthetic treatments by some of the best doctors in the country. ...
(Date:8/28/2020)... ... August 28, 2020 , ... Dr. Mark Surrey has been in ... serves as a clinical professor in the Department of OBGYN at UCLA’s David Geffen ... & Pacific Coast Reproductive Society and is a Clinical Director of Fellowship Training for ...
(Date:8/27/2020)... , ... August 27, 2020 , ... The flu season is right round the corner ... well equipped with all the necessary measures before it begins to harbor its effects on ... and it is leaving a huge impact on our lives. Hence it has become even ...
Breaking Medicine Technology:
Cached News: