HOME >> MEDICINE >> NEWS
First major study of mammalian 'disorderly' proteins

Investigators at St. Jude Children's Research Hospital turned up the heat on "disorderly" proteins and confirmed that most of these unruly molecules perform critical functions in the cell. The St. Jude team completed the first large-scale collection, investigation and classification of these so-called intrinsically unstructured proteins (IUPs), a large group of molecules that play vital roles in the daily activities of cells.

The new technique for collecting and identifying IUPs is important because although scientists have been aware of the existence of flexible proteins for many years, they have only recently realized that these molecules play major biological roles in the cell, according to Richard Kriwacki, Ph.D., an associate member of the St. Jude Department of Structural Biology. Moreover, he said, previous work by other researchers suggested that a large proportion of IUPs in mammalian cells play key roles in transmitting signals and coordinating biochemical and genetic activities that keep the cell alive and functioning. Kriwacki is senior author of a report on this work that appears in the prepublication online issue of Journal of Proteome Research.

"Until now there was no way to separate IUPs in large numbers from the more structured proteins and confirm their roles in the cell," Kriwacki said. "Our new technique selectively concentrates the IUPs that are involved in regulating functions in the cell and transmitting signals within them."

Unlike the classic description of proteins described in science textbooks, IUPs are not completely locked into rigid, 3-D shapes that determine their function in the cell. Instead, IUPs have varying amounts of flexibility within their sometimes spaghetti-like structures that is critical for function. For example, one protein named p27 initially looks like a SlinkyTM toy. However, when p27 goes to work, it puts a vise-like grip on an enzyme that otherwise would promote uncon
'"/>

Contact: Bonnie Kourvelas
bonnie.kourvelas@stjude.org
901-495-4815
St. Jude Children's Research Hospital
9-Oct-2006


Page: 1 2

Related medicine news :

1. First of its kind report on how children with brain tumors perform at school
2. First clinical trial of gene therapy for childhood blindness
3. First nationwide child health and air pollution study commences
4. First step in developing heart hormone-based pill to control high blood pressure
5. First greenhouse gas animations produced using Envisat SCIAMACHY data
6. First ozone and nitrogen dioxide measurements from MetOp-A
7. First-degree fetal heart block may be reversible
8. 10 outstanding scientists chosen as First Environmental Health Science Fellows
9. First-time mothers at increased risk for postpartum mental disorders
10. Transforming knowledge into economic benefits -- EPSRCs First Knowledge Transfer Challenge Awards
11. First Quantum Grant to fund stem cell repair of damage from stroke

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic surgeons at Allegheny General ... Carnegie Mellon University (CMU) to develop a new heart monitoring device designed to ... surgery. , The AGH/CMU team was recently awarded a “Trailblazer” grant from the ...
(Date:8/31/2020)... ... August 31, 2020 , ... Want to get moving, break ... Alliance Research Foundation (CPARF) is thrilled to launch its fourth annual STEPtember campaign in ... virtual challenge, STEPtember meets everyone wherever they are at this moment — encouraging people ...
(Date:8/31/2020)... ... 2020 , ... The pandemic and topsy-turvy economic outlook continues to put financial strain on many ... to trim the fat from our monthly expenses and put more into savings, if possible. ... you have a financial safety net in place in case something were to happen to ...
(Date:8/31/2020)... ... August 31, 2020 , ... Bonde Innovations, ... patients with advanced heart failure, today announced that the company has been awarded ... $555,358 from the National Heart, Lung, and Blood Institute of the National Institutes ...
(Date:8/28/2020)... ... 28, 2020 , ... The 15 scholarships being offered by ... Wellness mobile app and web-portal. NCPCV received a 2020 grant from Motorola Solutions ... year to organizations, such as Destination Imagination, which support and advance public safety ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... August 26, 2020 , ... As the U.S. struggles in ... routine for preventing the Coronavirus. Wear a mask, keep your distance, wash your hands. ... Denis Burkitt said it best in 1977, “How much better it is to prevent ...
(Date:8/26/2020)... ... August 26, 2020 , ... Hero Life Sciences announced today ... million 3 ply surgical disposable face masks and N95 respirators in its manufacturing plant ... the challenge that most Americans are facing in trying to find quality disposable face ...
(Date:8/26/2020)... DIEGO (PRWEB) , ... August 26, 2020 , ... ... announced today the appointment of Claude E. Hooton as President and Chief Executive ... role of Executive Chairman of the company’s Board of Managers. , Mr. ...
Breaking Medicine Technology:
Cached News: