HOME >> MEDICINE >> NEWS
First major study of mammalian 'disorderly' proteins

Investigators at St. Jude Children's Research Hospital turned up the heat on "disorderly" proteins and confirmed that most of these unruly molecules perform critical functions in the cell. The St. Jude team completed the first large-scale collection, investigation and classification of these so-called intrinsically unstructured proteins (IUPs), a large group of molecules that play vital roles in the daily activities of cells.

The new technique for collecting and identifying IUPs is important because although scientists have been aware of the existence of flexible proteins for many years, they have only recently realized that these molecules play major biological roles in the cell, according to Richard Kriwacki, Ph.D., an associate member of the St. Jude Department of Structural Biology. Moreover, he said, previous work by other researchers suggested that a large proportion of IUPs in mammalian cells play key roles in transmitting signals and coordinating biochemical and genetic activities that keep the cell alive and functioning. Kriwacki is senior author of a report on this work that appears in the prepublication online issue of Journal of Proteome Research.

"Until now there was no way to separate IUPs in large numbers from the more structured proteins and confirm their roles in the cell," Kriwacki said. "Our new technique selectively concentrates the IUPs that are involved in regulating functions in the cell and transmitting signals within them."

Unlike the classic description of proteins described in science textbooks, IUPs are not completely locked into rigid, 3-D shapes that determine their function in the cell. Instead, IUPs have varying amounts of flexibility within their sometimes spaghetti-like structures that is critical for function. For example, one protein named p27 initially looks like a SlinkyTM toy. However, when p27 goes to work, it puts a vise-like grip on an enzyme that otherwise would promote uncon
'"/>

Contact: Bonnie Kourvelas
bonnie.kourvelas@stjude.org
901-495-4815
St. Jude Children's Research Hospital
9-Oct-2006


Page: 1 2

Related medicine news :

1. First of its kind report on how children with brain tumors perform at school
2. First clinical trial of gene therapy for childhood blindness
3. First nationwide child health and air pollution study commences
4. First step in developing heart hormone-based pill to control high blood pressure
5. First greenhouse gas animations produced using Envisat SCIAMACHY data
6. First ozone and nitrogen dioxide measurements from MetOp-A
7. First-degree fetal heart block may be reversible
8. 10 outstanding scientists chosen as First Environmental Health Science Fellows
9. First-time mothers at increased risk for postpartum mental disorders
10. Transforming knowledge into economic benefits -- EPSRCs First Knowledge Transfer Challenge Awards
11. First Quantum Grant to fund stem cell repair of damage from stroke

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/7/2018)... ... 07, 2018 , ... Guruji Mahendra Trivedi is an innovative ... practical and spiritual levels. Founder of the Trivedi Effect®, Guruji Mahendra Trivedi will ... by Navratri, is a mystical time when Divine Energy is at its peak ...
(Date:10/6/2018)... ... October 06, 2018 , ... The iaedp™ ... who treat the full spectrum of eating disorders (ED), today welcomed KellerLife Center ... “As with each of our Presidents Council members, it is an honor for ...
(Date:10/6/2018)... (PRWEB) , ... October 06, 2018 , ... ... local and international clients in Miami. , Haute Beauty, well known for ... Feliz as a leading aesthetic surgeon and our newest addition to the Haute ...
(Date:10/5/2018)... ... October 05, 2018 , ... Shofner Vision ... surgery to patients residing in middle Tennessee and surrounding areas. Recognized by his ... States, Dr. Stewart Shofner has performed over 40,000 LASIK procedures and ...
(Date:10/5/2018)... (PRWEB) , ... October 05, 2018 , ... ... Health Conference (CHC) 2018, an annual conference on the latest innovations in health ... this year’s event Oct. 8-11 throughout downtown Kansas City, Missouri. , "We’re really ...
Breaking Medicine News(10 mins):
(Date:10/5/2018)... ... October 05, 2018 , ... A September 20th article in the Richmond Times-Dispatch reports ... The death was ruled to be the result of a head trauma. As the article ... a new California law legalizing helmetless scooter driving for adults. Los Angeles based ...
(Date:10/5/2018)... ... 05, 2018 , ... TeamLogic IT franchisees gathered in Irvine, ... franchisees attended the event, which also featured the largest vendor show to-date. TeamLogic ... features several keynote general sessions, breakout seminars, workshops, and roundtable discussions as well ...
(Date:10/3/2018)... , ... October 03, 2018 , ... ... clinical outcomes, today announced the introduction of Intalere REVolutionSM Laboratory Consulting Solution, designed ... their laboratories of 10% or greater. , “Laboratories across the country are faced ...
Breaking Medicine Technology:
Cached News: