HOME >> MEDICINE >> NEWS
First step in developing heart hormone-based pill to control high blood pressure

NEW ORLEANS -- In an era of increasing death and illness from heart and blood vessel disease -- which also can impair kidney function -- Mayo Clinic researchers have designed two promising new cardiovascular treatment approaches. In the process, they have overcome a key technological hurdle that has stymied researchers around the world in the development of new therapies based on clusters of amino acids called peptides. The Mayo Clinic researchers will present their findings March 27 at the American College of Cardiologys 56th Annual Scientific Sessions.

Significance of the Mayo Clinic Research

The first advance supports the feasibility of developing a peptide-based drug that can be given in pill form to lower high blood pressure, and that is based on a hormone originating in the heart, called B-type natriuretic peptide (BNP).

"Our formulation of an oral peptide is a technological accomplishment that really can advance the field," says John Burnett, Jr., M.D., director of Mayo Clinics Cardiorenal Research Lab who led both studies. "Prior to this, it was unheard of that a peptide could be given orally, because it is so rapidly degraded by stomach enzymes. Yet we overcame this significant constraint. This is the first report demonstrating that a peptide -- in this case, BNP -- can be developed by innovative technology to be absorbed orally."

The second advance is the development of a therapeutic hybrid molecule that helps improve both heart and kidney function. Addressing kidney blood vessel disease in addition to heart vessel disease is an increasingly important clinical focus for therapies as kidney failure becomes epidemic in the 21st century, and diseases of both heart and kidney link the health of the two organ systems.

Heart Hormone Pill for High Blood Pressure

Heart disease continues to be a leading cause of death and disability in Western countries, and kidney disease is a fast-gro
'"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
27-Mar-2007


Page: 1 2 3

Related medicine news :

1. First of its kind report on how children with brain tumors perform at school
2. First clinical trial of gene therapy for childhood blindness
3. First nationwide child health and air pollution study commences
4. First greenhouse gas animations produced using Envisat SCIAMACHY data
5. First ozone and nitrogen dioxide measurements from MetOp-A
6. First-degree fetal heart block may be reversible
7. 10 outstanding scientists chosen as First Environmental Health Science Fellows
8. First-time mothers at increased risk for postpartum mental disorders
9. Transforming knowledge into economic benefits -- EPSRCs First Knowledge Transfer Challenge Awards
10. First Quantum Grant to fund stem cell repair of damage from stroke
11. First major study of mammalian disorderly proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: