First step in developing heart hormone-based pill to control high blood pressure

wing threat to public health. These two disease processes are linked by the fact that they both are often the result of high blood pressure. "New treatment strategies are therefore urgently needed," Dr. Burnett says. In tackling heart disease, Mayo Clinic researchers considered the heart from a different perspective -- not merely a mechanical pump, as it is traditionally regarded, but as a hormone-secreting endocrine organ.

"To view the heart this way is a distinct innovation that presents new opportunities for cures that weve made good progress toward exploring," Dr. Burnett says. The researchers were the first to harness the natural properties of the heart hormone BNP, working in partnership with scientists from the biotechnology firm, Biocon, and to formulate it so it can be taken orally, in pill form. BNPs therapeutic properties include its ability to dilate blood vessels, promote salt discharge in urine, and prevent both excessive cell growth and growth of fibrous tissues. The researchers tested the oral BNP by inducing high blood pressure in laboratory animals, and then giving them the experimental drug. Results showed that the experimental oral drug reduced the mean arterial pressure steadily over time, beginning at 30 minutes after the oral treatment was given, and continuing to reduce blood pressure for two hours, the studys endpoint.

"Clearly, this novel oral form of BNP significantly reduces mean arterial pressure in an experimental model of high blood pressure," says Dr. Burnett. "Our findings are both exciting and important because they advance an innovative strategy of orally administering BNP therapy for cardiovascular diseases such as high blood pressure."

The Heart-Kidney Link

In heart failure, the kidneys also can become impaired and salt and water retention can occur, resulting in congestion. Reduced kidney function leads to buildup of toxins in the blood that can disable a person -- and progre

Contact: Traci Klein
Mayo Clinic

Page: 1 2 3

Related medicine news :

1. First of its kind report on how children with brain tumors perform at school
2. First clinical trial of gene therapy for childhood blindness
3. First nationwide child health and air pollution study commences
4. First greenhouse gas animations produced using Envisat SCIAMACHY data
5. First ozone and nitrogen dioxide measurements from MetOp-A
6. First-degree fetal heart block may be reversible
7. 10 outstanding scientists chosen as First Environmental Health Science Fellows
8. First-time mothers at increased risk for postpartum mental disorders
9. Transforming knowledge into economic benefits -- EPSRCs First Knowledge Transfer Challenge Awards
10. First Quantum Grant to fund stem cell repair of damage from stroke
11. First major study of mammalian disorderly proteins

Post Your Comments:

(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... leader in post-acute health care, have expanded their existing home health joint venture ... , AccentCare has been operating a joint venture home health company with Asante, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... HMP ... the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare ... City on October 11, 2017. , The annual award competition recognizes editorial and design ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017  NDS received FDA 510(k) clearance in May ... battery-powered display stand specifically designed for endoscopy environments. An innovative secondary ... a clinical solution to support the improvement of patient outcomes, procedural ... ... ...
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
Breaking Medicine Technology:
Cached News: