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Fluorescence device to diagnose atherosclerosis and tumors described at optics conference

or guide therapeutic interventions to prevent plaque rupture. It may be that our probe will be attached to an angioscope or to an intravascular ultrasound catheter to investigate the plaque," said Laura Marcu, Ph.D., director of the Biophotonics Research and Technology Development Laboratory in Cedars-Sinai's Department of Surgery.

"Results of spectroscopic examinations might be used to determine the most effective drug or treatment approach for a particular plaque. Physicians would be able to use this technology to determine whether plaque is stable or unstable, and they could use it to monitor the efficacy of a therapy. One of our next steps is to develop an intravascular catheter that will enable routine use of this technology in vivo, or in patients," said Marcu, who will make the 10:45 a.m. presentation titled "Applications of Time-Resolved Fluorescence Spectroscopy to Atherosclerotic Cardiovascular Disease and Brain Tumors Diagnosis."

In tests conducted on brain tumor tissue removed from 50 patients, TR-LIFS has been able to distinguish various types of brain tumor tissue from normal tissue. Furthermore, preliminary data collected from 17 patients during neurosurgery show that the technique can detect tumor cells left behind after tumor removal.

Neurosurgeon Keith L. Black, M.D., director of Cedars-Sinai's Maxine Dunitz Neurosurgical Institute, said he is encouraged by the clarity that fluorescence technology may offer, especially because the most deadly tumors aggressively infiltrate neighboring tissue and are irregularly shaped with poorly defined borders. "Although our surgical goal is to remove as much tumor as possible without damaging healthy brain, distinguishing between the two can be extremely difficult, even with the sophisticated imaging techniques currently available," he said.

The TR-LIFS apparatus consists of a laser, a two-way fiber-optic probe through which the laser light is delivered to the tissue and the flu
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Contact: Sandy Van
sandy@prpacific.com
1-800-880-2397
Cedars-Sinai Medical Center
27-May-2005


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