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Fluorescence device to diagnose atherosclerosis and tumors described at optics conference

orescence is collected, a spectrometer, a digital oscilloscope, and a computer workstation that provides user interface, coordination of components and interpretation software. While the components are now small enough to fit on a portable cart that can be taken into an operating room, additional studies on miniaturization of components and instruments are planned. In fact, the National Institutes of Health is providing funding for the development of microdevices.

While the basic hardware and software is the same whether brain tumors or blood vessels are being studied, the way the system operates is dependent on the unique characteristics of the tissue.

"Each biological system will be characterized by a distinct chemical composition, different molecules and different ways of identifying them," said Marcu. "Therefore, to be sure the technology addresses particular questions and issues related to brain tumors, we must collect data from patients, analyze the data and define the spectral ranges of particular aspects related to the diagnosis of brain tumors. But those are very different from those related to atherosclerosis."

The studies presented were supported by the National Institutes of Health, Grant #R01 HL 67377, and The Whitaker Foundation, Grant #RG-01-0346.

The studies on atherosclerotic plaques were conducted in collaboration with Michael C. Fishbein, M.D., and J. Dennis Baker, M.D., at UCLA Medical School and Julie A. Freischlag, M.D., at Johns Hopkins University. The studies on brain tumors were in collaboration with Keith L. Black, M.D., Brian K. Pikul, M.D., and William H. Yong, M.D., at Cedars-Sinai.

The Conference on Lasers and Electro-Optics (CLEO) is being held in conjunction with the Quantum Electronics and Laser Science (QELS) Conference at the Baltimore Convention Center from May 22 through 27. In addition to the May 27 presentation, Marcu was invited to preside over a series of sessions on Microfluidics, Flow
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Contact: Sandy Van
sandy@prpacific.com
1-800-880-2397
Cedars-Sinai Medical Center
27-May-2005


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