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Fluorescence diffuse optical tomography provides high contrast, 3-D look at breast cancer

PHILADELPHIA -- Researchers at the University of Pennsylvania have created the first three-dimensional optical images of human breast cancer in patients based on tissue fluorescence.

Fluorescence diffuse optical tomography, or FDOT, relies on the presence of fluorophore molecules in tissue that re-radiate fluorescent light after illumination by excitation light of a different color. The reconstructed images demonstrated significant tumor contrast compared to typical endogenous optical contrast in breast. Tumor-to-normal tissue contrast based on FDOT with the fluorophore Indocyanine Green, or ICG, was two-to-four-fold higher than contrast based on endogenous contrasts such as hemoglobin and scattering parameters obtained with traditional diffuse optical tomography, or DOT.

With the continued development of molecularly-targeted exogenous fluorophores, the research helps pave the way for diagnostic tools based on optics that will provide improved sensitivity and specificity between healthy and normal tissues.

Fluorophores are exquisitely sensitive to their local environment, and therefore FDOT holds potential to provide information about tumor physiology, including tissue oxygen, tissue pH and tissue calcium concentration levels.

Previously, the FDOT technique was used for in-vivo imaging of animal tissues, but ours is the first successful demonstration of its use to detect cancer in deep-tissue, human breast imaging, Arjun Yodh, professor of physics at Penn, said.

DOT uses near-infrared light to scan and provide cross-sectional and volumetric views of biological tissue. It is promising as a tool to characterize lesions and monitor therapy; however, its resolution is not as high as other anatomically oriented imaging modalities, and contrast comes mainly from vasculature abnormalities.

In the current study using FDOT, the intravenous addition of an exogenous molecular agent, ICG, was used to enhance tumor contrast. Th
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Contact: Jordan Reese
jreese@pobox.upenn.edu
215-573-6604
University of Pennsylvania
13-Jun-2007


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