Through age 5, children born at full term with low birth weight show significantly greater risk for developing respiratory symptoms, including wheezing, coughing and pulmonary infections, according to a large longitudinal study on birth weight and development. The children's symptoms grew worse if they were exposed to environmental tobacco smoke.

The research results appear in the second issue for May 2007 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Professor Johan C. de Jongste, M.D., Ph.D., of the Department of Pediatric Respiratory Medicine at Erasmus MC/Sophia Children's Hospital in The Netherlands, and eight associates studied 3,628 children who took part in the 1996 Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study, which analyzed children's allergic reactions and history of asthma.

The researchers concluded that the effect of birth weight on respiratory symptoms increased, from ages 1 to 5, in direct relation to birth weight per kilogram less in each child. However, after age 5, the effect lessened and was not significant by age 7. The authors defined low birth weight as 5.5 pounds at birth.

"Size and maturity are major factors in the development of the lung," said Dr. de Jongste. "In children with diminished prenatal growth, and consequently low birth weight, a disturbed lung development is associated with a relatively small airway caliber. This can cause decreased lung function and more respiratory symptoms later in life."

According to the investigators, the effect of birth weight on respiratory symptoms was significantly greater among children exposed to tobacco smoke in their home. They also noted that maternal smoking during pregnancy was "clearly associated with a reduced birth weight."

By age 2, cough was the most frequently reported symptom among the children. Between the ages of 4 and 7, abou
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Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
15-May-2007