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Garlic hope in infection fight

Garlic has been hailed a wonder drug for centuries and has been used to prevent gangrene, treat high blood pressure, ward off common colds and is even believed by some to have cancer-fighting properties.

Now, scientists at The University of Nottingham are leading a new pilot study to see if the pungent bulb could also hold the key to preventing cystic fibrosis patients from falling foul of a potentially-fatal infection.

The research will look at whether taking garlic capsules can disrupt the communication system of the pathogen Pseudomonas to prevent illness from taking hold.

The project will unite University experts in child health, respiratory medicine and molecular microbiology with clinicians at the Nottingham University Hospitals NHS Trust.

Cystic fibrosis is an inherited condition that affects around 7,000 people in the UK, half of whom are children. The disease causes difficulties in digesting food and children may be slow to put on weight and grow properly. Both children and adults with the condition are vulnerable to repeated and chronic chest infections which damage the lungs and which may, ultimately, be fatal.

Pseudomonas aeruginosa is one of the most common causes of chronic infection in CF patients. Current treatment aims to eradicate it when it first appears. If the infection becomes established it may be suppressed with antibiotic nebulisers. However, these have a major impact on quality of life for the patient because they are time-consuming (given twice a day, every day, for life) and often the patient still has to be admitted to hospital for more intensive treatment.

During the study, half the volunteer CF patients will be given garlic capsules, while the other half will receive a placebo (olive oil capsules) over a two month period. At the beginning and end of the study, researchers will measure the levels of germs in patients' sputum samples, the patients' lung function and weight wi
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Contact: Dr Alan Smyth
alan.smyth@nottingham.ac.uk
44-011-582-31703
University of Nottingham
31-Jan-2007


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