A preliminary study suggests that topical application of a gel made from platelets in healthy individuals own blood may help wounds heal more quickly and completely, according to a report in the May/June issue of Archives of Facial Plastic Surgery, one of the JAMA/Archives journals.

Recent innovations have led to devices that can process blood into a concentrated plasma rich in platelets (particles important for blood clotting), and then to an autologous (from the patients own body) platelet gel, according to background information in the article. This gel is currently used in surgery to improve healing, but its clinical application remains controversial.

David B. Hom, M.D., then of the University of Minnesota School of Medicine and Hennepin County Medical Center, Minneapolis, and now at the University of Cincinnati College of Medicine, and colleagues assessed the effectiveness of autologous platelet gel in eight healthy men and women older than 21 years. Five 4-millimeter skin punch wounds were made 3 centimeters apart on both the right and left upper thighs in all eight individuals. The autologous platelet gel was applied to the wounds on one leg, while the wounds on the other leg were treated with only an antibiotic ointment or a dressing. The wounds were monitored by the researchers and were digitally photographed for six months, and additional biopsies (removal of skin) were performed on each leg.

During the six-month follow-up, none of the participants developed infections and no serious adverse events were reported. "Over a 42-day period, the autologous platelet geltreated sites had statistically increased wound closure compared with controls by visual clinical assessment and by digital planimetry [boundary-tracing] photographic measurements," the authors write. "On day 17, the percentage of closure was 81.1 percent for the autologous platelet geltreated sites and 57.2 percent for the control sites."

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JAMA and Archives Journals
21-May-2007