HOME >> MEDICINE >> NEWS
Gene linked to lower breast cancer risk

Dr. Uwe Langsenlehner and colleagues from Medical University Graz in Austria showed that a specific genetic variation in a cytokine gene is associated with lower breast cancer risk.

Cytokines are molecules that act as signals between cells. The authors were examining the cytokine IL 10, which is involved in the development of various tumors.

"In breast cancer risk, IL-10 may be a two-edged sword," Dr. Langsenlehner said. "On one hand, higher IL-10 levels could facilitate development of cancer by supporting tumor escape from the immune response. On the other hand, the anti-angiogenic effects of IL-10 are supposed to prevent or reduce tumor growth and spread."

Specifically, the Austrian team examined a particular genetic arrangement, or haplotype, in the promoter region of the gene, which has been associated with increased IL-10 expression. The researchers call this the TCATA haplotype.

In a study comparing 500 women with breast cancer against 500 health controls, they found that breast cancer patients were significantly less likely to have two versions of the TCATA haplotype.

"Our study suggests that high levels of IL-10 may be protective against breast cancer," Dr. Langsenlehner said. "The mechanism for this remains to be determined, but may likely include anti-angiogenic functions of IL-10. If this result can be confirmed in additional studies, determination of IL 10 genotypes may help to obtain a more precise individual breast cancer risk profile."


'"/>

Contact: Gracemarie Bricalli
gracemarie@esmo.org
41-91-973-1911
European Society for Medical Oncology
6-Jun-2005


Page: 1

Related medicine news :

1. Pot bellies linked to early signs of cardiovascular disease
2. Reductive stress linked to heart disease
3. Obesity linked to hyperparathyroidism in chronic kidney disease
4. Studies show antidepressants not linked to birth defects
5. Low libido in menopause linked to trouble sleeping
6. Performance-related financial incentives for hospitals not linked with improved quality of care
7. Low-carb diets effects linked to rise in newly identified starvation hormone
8. Harboring hostility may be linked to unhealthy lungs
9. Protein may be linked to melanoma recurrence
10. Cedars-Sinai endocrine researchers to discuss gene that may be linked to polycystic ovary syndrome
11. ICU nurse working conditions linked to increase in patient infections

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... , ... The American Medical Spa Association (AmSpa) has announced ... April 10, 2021, at Wynn Las Vegas. The event had previously been scheduled ... non-invasive medical aesthetic practices that brings together owners, physicians, nurse practitioners, physician assistants ...
(Date:9/1/2020)... ... September 01, 2020 , ... Board certified plastic surgeon Sepideh ... office will be the first to bear her name, Dr. Saber has regularly ... lift), as well as rhinoplasty, facial rejuvenation, and many more in association with ...
(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran Gill is ... surgery of the face, breast, and body. In 2018, she founded Aesthetics in ... surgery and aesthetic practice in Southwest Florida. Dr. Gill and her team offer ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean ... face masks to medical first responders across the United States. Since the start ... personal protective equipment (PPE) medical centers , hospitals , firefighters ...
(Date:8/31/2020)... ... August 31, 2020 , ... Smile Brands ... groups in the United States, today announced the grand opening of another affiliated ... , Patients will enjoy convenient hours, a comfortable office, and full-service care at ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... September 03, 2020 , ... Q&J Face Masks announced today ... aerosol and engineering lab, conducted tests on Q&J’s personal face mask that indicated ... many other masks. Q&J face masks have both mechanical filtering and electrostatic filtering ...
(Date:9/2/2020)... Texas (PRWEB) , ... September ... ... in the Fight Against Covid-19 , Advanced Penetration Technology, LLC, (APT) a ... solutions for patients utilizing non-prescription, Over The Counter (OTC) products, was today ...
(Date:9/1/2020)... ... September 01, 2020 , ... Neil Oberfeld of global law ... the Board of Trustees and committee chair of the Governance Committee for Mile ... nonprofit organization that fights for the education, health, and financial stability of residents ...
Breaking Medicine Technology:
Cached News: