HOME >> MEDICINE >> NEWS
Gene therapy potential for treatment of pancreatic cancer

A gene responsible for the production of a protein called vasostatin may prove a promising new way of treating pancreatic cancer, suggests research published ahead of print in Gut.

Pancreatic cancer is the fifth leading cause of cancer deaths in the developed world, and is extremely difficult to treat. Only 3% of affected patients are still alive five years after diagnosis, a survival rate that has remained static for the past three decades.

Currently, the only viable treatment is surgery. Radiotherapy and chemotherapy have little impact on the disease.

The research team investigated the potential of the protein vasostatin to suppress the development of new blood vessels and pancreatic tumour cells both in test tubes and in mice with pancreatic cancer.

'Solid' tumours, such as pancreatic cancer, are heavily dependent on a rich blood supply to enable them to grow rapidly and spread throughout the body. This process is known as angiogenesis.

The protein gene was incorporated into a virus (adenovirus), so that it would be able to penetrate the cells, acting as a vector.

The test tube experiments showed that 72 hours after infection with the genetically modified virus, vasostatin was clearly active in the tissue. Tumour growth in the mice was also curbed, and when compared with mice which had not been infected with the virus, the difference between the two groups was highly significant.

The researchers then looked more closely at the pancreatic cells and the cell linings of the blood vessels (vascular endothelial cells).

They found that although vasostatin seemed to have little impact on the pancreatic cells, it blocked the formation of new blood vessels, effectively cutting off the supply of nutrients to the malignant cells. This effect was seen in both the test tube and animal experiments.

This type of gene therapy "may be a potent strategy to treat many malignant tumours, including pancreatic ca
'"/>

Contact: Tersea Hagan
thagan@bma.org.uk
020-738-36174
BMJ Specialty Journals
14-Nov-2005


Page: 1 2

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
3. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
4. Hormone therapy offers new hope for ovarian cancer patients
5. Borderline personality disorder shows improvements with intensive psychotherapy
6. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
7. Chemotherapy may enhance the effectiveness of brain tumor vaccines
8. Brain-boosting pill alleviates post-chemotherapy fogginess
9. Adding radioimmunotherapy to chemo may help patients with lymphoma
10. Pre-operative chemotherapy does not increase survival rates for nonsmall cell lung cancer
11. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... ... August 21, 2019 , ... ... automated x-ray inspection technology: HDRX imaging. HDRX captures extremely high-resolution images of ... HDRX can deliver high image resolution at normal production line speeds within ...
(Date:8/19/2019)... ... August 19, 2019 , ... AJG Packaging, ... announced the availability of resealable single-dose vials for a multitude of applications. The ... consists of five resealable breakaway vials and are available in either polyethylene or ...
(Date:8/19/2019)... ... August 19, 2019 , ... American ... necessary and cosmetic procedures in 2018 – 7.5 percent more than 2017 and ... 2018 ASDS Survey on Dermatologic Procedures revealed skin cancer treatments are ...
(Date:8/19/2019)... ... August 19, 2019 , ... ... and San Antonio, Texas, proudly announces they have ranked #3056 on the 2019 ... and represents a unique look at the most successful companies within the American ...
(Date:8/19/2019)... NEW YORK (PRWEB) , ... August 19, 2019 , ... ... turning the spotlight on the best hair restoration doctors in New York currently providing ... as well as those starting to see some thinning hair. Cosmetic Town makes the ...
Breaking Medicine News(10 mins):
(Date:8/21/2019)... , ... August 21, 2019 , ... ... experience by lowering pool chemical use with Clear Comfort’s Advanced Oxidation Process (AOP) ... to save significant chemical expense dollars, simplify its water care protocol and improve ...
(Date:8/19/2019)... ... August 19, 2019 , ... ... hosting their 2nd Annual National Sports Summit, August 25-26 at the Hyatt Place ... clinical leaders from all major professional sports programs to discuss progress made over ...
(Date:8/19/2019)... ... August 19, 2019 , ... ... announced the findings of research validating the clinical impact of MedAware’s machine learning-enabled ... 7 August 2019 in the Journal of American Medical Informatics Association (JAMIA) ...
Breaking Medicine Technology:
Cached News: