Finding that so many primary-care patients use such medications suggests that pharmacogenetics--the study of the interplay between genes and drugs--has the potential to benefit a large portion of the population, according to the researchers. Applying information from pharmacogenetics to primary-care practices could reduce the incidence of adverse reactions and optimize treatments, according to the study, published in the January 2006 issue of the journal Pharmacogenomics.
"Until now, researchers looking at the role of genetic variation in drug effects have focused mainly on toxic drugs used by specialists treating cancer or HIV infection," says Howard L. McLeod, Pharm.D., director of the pharmacology core at the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. "We knew that some of the drugs commonly used in the family practice setting can cause adverse reactions in people who have certain genetic variations, so we measured just how often these drugs are used."
The study found that of the 607 outpatients surveyed at three primary-care sites in the metropolitan St. Louis area, 174 were on a drug commonly associated with severe side effects. Among these drugs are fluoxetine (Prozac), metoprolol (a beta-blocker), diltiazem (used to treat high blood pressure), and warfarin (an anticoagulant).
Each of these drugs is metabolized by genes known to vary within the population. Genetic variations that change the properties of enzymes that break down drugs or mark them for excretion can cause adverse d
Contact: Gwen Ericson
Washington University School of Medicine