HOME >> MEDICINE >> NEWS
Genetic variation linked to age-related macular degeneration

The combination of a certain genetic variation, along with inflammatory factors and smoking, significantly increases the risk of the vision disorder age-related macular degeneration, according to a study in the July 19 issue of JAMA.

Age-related macular degeneration (AMD) is the most important cause of irreversible visual loss in the elderly of the Western world, according to background information in the article. It has long been recognized that hereditary factors play a role in AMD and there is increasing evidence that inflammation is an important disease mechanism. Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of the complement pathway, and AMD.

Dominiek D. G. Despriet, M.D., of the Erasmus Medical Center, Rotterdam, the Netherlands, and colleagues hypothesized that the effect of this regulator gene may be particularly hazardous in persons in whom the complement cascade is activated. They assessed the association between the CFH gene and AMD and investigated the modifying effect of smoking, serum inflammatory markers, and genetic variation of C-reactive protein (CRP). The population-based study included 5,681 individuals age 55 years or older who were assessed for the gene mutation CFH Y402H. Information on smoking, serum inflammatory markers and CRP gene variation were assessed at baseline.

The frequency of CFH Y402H was 36.2 percent. At baseline, there were 2,062 persons (36.3 percent) with any type of AMD (prevalent cases), including 78 (1.4 percent) with late AMD. During an average follow-up of 8 years, 1,649 (35.5 percent) of 4,642 participants progressed to a higher stage of AMD (new cases), including 93 (5.6 percent) who developed late AMD.

The researchers found that the CFH gene was a major risk factor for AMD in the general population. The gene was implicated in all stages of AMD from early hallmarks such as drusen (material that builds up in the
'"/>

Contact: Paulus de Jong
p.dejong@nin.knaw.nl
JAMA and Archives Journals
18-Jul-2006


Page: 1 2

Related medicine news :

1. Genetic variations may predispose some men to suicidal thoughts during treatment for depression
2. Genetic mutations identified for type of gastric cancer
3. Genetic marker linked to aggressive prostate cancer
4. Genetic markers in surrounding tissues linked to breast cancer tumor grade, presence of metastases
5. Genetic pathways to curable and incurable forms of pancreatic cancer identified
6. Genetically modified cells attack tumors
7. Genetic insights may explain retinal growth, eye cancer
8. Genetic perversity: Smoking & gene avert Parkinsons
9. Genetics plays role in relapse of illicit drug-seeking behavior
10. Genetic mutation linked to West Nile virus infection
11. Genetics plays a role in the side effects experienced by people taking painkillers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... Calif. (PRWEB) , ... September 01, 2020 , ... As ... “safe side”, the Cohn Health Institute has taken this time to expand ... celebration of its 30th Anniversary, the Cohn Health Institute will be relaunching its brand ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... 1,400 N95 face masks to medical first responders across the United States. Since ... donations of personal protective equipment (PPE) medical centers , hospitals , ...
(Date:8/31/2020)... ... ... pandemic and topsy-turvy economic outlook continues to put financial strain on many of us, so ... fat from our monthly expenses and put more into savings, if possible. , “That’s a ... financial safety net in place in case something were to happen to you,” says Lee ...
(Date:8/29/2020)... ... , ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, ... than become melancholic, however, he put together a final lecture in Carnegie Hall in ... a negative situation and turned it into something that inspired millions of people worldwide. ...
(Date:8/28/2020)... ... ... Integrated Viral Protection (IVP Air) today announced that the True North Classical ... Indoor Air Protection System that is the first system designed and proven to catch ... the filtration system on September 8th. , The IVP Air S1 model is ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... If you live in New York City you will ... part makes sense, it’s the law of supply and demand, but are plastic surgeons in ... a significant percentage of their patients that make the four-hour trip to have expert aesthetic ...
(Date:8/28/2020)... ... August 28, 2020 , ... Cano Health, LLC, ... in Florida and San Antonio is happy to announce that it has selected ... In this capacity he will serve as community advisor, advertising talent, and creative ...
(Date:8/27/2020)... , ... August 27, 2020 , ... ... software, today announced the successful completion of their 2020 System and Organizational Controls ... their HITRUST® interim assessment and MARS-E compliance assessment. These achievements reflect their long-standing ...
Breaking Medicine Technology:
Cached News: