HOME >> MEDICINE >> NEWS
Genetically modified cells migrate to brain and treat neurodegeneration in St. Jude model

Physicians might one day be able to treat a disease that destroys brain cells in children using genetically modified cells to transport a "drug" to the site of the dying neural cells (cells that transmit impulses). This discovery occurred based on results of a laboratory study of the technique published by investigators at St. Jude Children's Research Hospital. A report on this work appears in the prepublication online issue of Blood.

There is currently no cure for such disorders, which are called lysosomal storage diseases (LSDs).

The St. Jude researchers successfully treated a laboratory model of an LSD called GM1 gangliosidosis using bone marrow cells (BMCs) into which scientists inserted the gene for an enzyme that breaks down a fat molecule called GM1. GM1 is a critical component of normal brain cells. But in GM1 gangliosidosis, brain cells lack this enzyme--beta-galactosidase--and GM1 accumulates to such a high concentration that it disrupts the proper function of the cell and causes it to self-destruct. BMCs include a population of so-called pluripotent stem cells--cells that give rise to a variety of different cell types that have specific functions, such as the immune cells called monocytes.

After the St. Jude team infused the genetically modified BMCs into the laboratory model, resulting monocytes migrated to the degenerating brain cells that lacked the gene for beta-galactosidase. These cells took in the enzyme released by the monocytes and used it to break down excess GM1, thus correcting the potentially fatal buildup of this molecule.

The monocytes homed in on the brain by following a trail of signaling molecules that were released by cells adjacent to the degenerating neurons, according to Alessandra d'Azzo, Ph.D., a member of the St. Jude department of Genetics and Tumor Cell Biology. Such signaling proteins are called chemokines. Under a disease condition, these brain cells, called astrocytes and microglia, release chemokines
'"/>

Contact: Kelly Perry
kelly.perry@stjude.org
901-495-3306
St. Jude Children's Research Hospital
22-Jun-2005


Page: 1 2 3

Related medicine news :

1. Genetically modified cells attack tumors
2. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
3. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
4. New algorithm matches any tumor cells to best possible anti-cancer treatments
5. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
6. Loss of stem cells correlates with premature aging in animal study
7. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
8. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
9. Stanford researchers track human stem cells transplanted into rat brain
10. Nurse cells make life and death decisions for infection-fighting cells
11. Adult brain cells rediscover their inner child

Post Your Comments:
(Date:7/23/2014)... Online medical service provider MeMD has appointed Dr. Nicholas ... Lorenzo joins the MeMD executive team with over 25 years ... of this remote treatment model, telemedicine. This is the type ... school, that someday we could treat people across the country. ... it hasn't been that long,” says Dr. Lorenzo. , After ...
(Date:7/23/2014)... 2014 Previously, the crew members for Maplewood’s ... spreadsheet. Now, the department’s 53 part-time members “self-schedule” ... Management system. , “Scheduling our personnel with paper and pencil, ... to keep track of when people could work, because they ... this time, and we would have to try to figure ...
(Date:7/22/2014)... 2014 Men and women who are ... portion of their disposable income each year on different ... its best anti aging products guide to help introduce ... guide is now released and accessible from any tablet, ... retailers were selected and inserted into the guide to ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 St. ... of the newest component of its existing telemedicine program- ... within the regional SSM Health Care of Oklahoma network. ... centers that shares its services with an even wider ... centers across several states. As a forward-thinking organization looking ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 DocbookMD ... process of deploying one of the largest physician-centric mobile ... ( MHMD ) in Houston. , Created by Austin-based ... the DocbookMD application will be embedded into MHMD’s Accountable ... searched for the best technology to put this capability ...
Breaking Medicine News(10 mins):Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 2Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 3Health News:This Fire Department Allows Personnel to Schedule Themselves - Saving Administration Up To 60 Hours a Month 2Health News:This Fire Department Allows Personnel to Schedule Themselves - Saving Administration Up To 60 Hours a Month 3Health News:Best Anti Aging Products Guide Launched for Natural Product Buyers Online at News Portal 2Health News:St. Anthony Hospital Expands Its Telemedicine Program with Telepsychiatry 2Health News:St. Anthony Hospital Expands Its Telemedicine Program with Telepsychiatry 3Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 3Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 4
(Date:7/22/2014)... /PRNewswire-iReach/ -- Reproductive Medicine Associates of New York ... a nationally and internationally-recognized leader in providing exceptional quality ... pleased to announce a new collaboration with EMD Serono ... recognize the sacrifices made by veterans and their families ... will allow qualifying veterans and the spouses of veterans ...
(Date:7/22/2014)... , July 22, 2014 BioDelivery Sciences ... that its Board of Directors has appointed Charles ... Feinberg as members of the Board.  ... with extensive experience in marketing, sales and other commercial ... Pearl Therapeutics, Inc., a development stage company that was ...
(Date:7/22/2014)... , July 22, 2014  NeuroSigma, Inc. (NeuroSigma), a ... on commercialization of its non-invasive Monarch ™ ... neuropsychiatric disorders, today announced that enrollment has begun in ... stimulation (eTNS) as adjunctive therapy for the treatment of ... conducted at the Olive View-UCLA Medical Center in ...
Breaking Medicine Technology:Reproductive Medicine Associates of New York Collaborates with EMD Serono to Offer Treatment Assistance to Eligible Veterans and their Spouses 2Reproductive Medicine Associates of New York Collaborates with EMD Serono to Offer Treatment Assistance to Eligible Veterans and their Spouses 3BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 2BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 3BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 4BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 5BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 6BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 7Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 2Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 3Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 4Enrollment Commences in NeuroSigma-Sponsored Pediatric Clinical Trial for the Treatment of Lennox-Gastaut Syndrome 5
Cached News: