HOME >> MEDICINE >> NEWS
Genetically modified cells migrate to brain and treat neurodegeneration in St. Jude model

Physicians might one day be able to treat a disease that destroys brain cells in children using genetically modified cells to transport a "drug" to the site of the dying neural cells (cells that transmit impulses). This discovery occurred based on results of a laboratory study of the technique published by investigators at St. Jude Children's Research Hospital. A report on this work appears in the prepublication online issue of Blood.

There is currently no cure for such disorders, which are called lysosomal storage diseases (LSDs).

The St. Jude researchers successfully treated a laboratory model of an LSD called GM1 gangliosidosis using bone marrow cells (BMCs) into which scientists inserted the gene for an enzyme that breaks down a fat molecule called GM1. GM1 is a critical component of normal brain cells. But in GM1 gangliosidosis, brain cells lack this enzyme--beta-galactosidase--and GM1 accumulates to such a high concentration that it disrupts the proper function of the cell and causes it to self-destruct. BMCs include a population of so-called pluripotent stem cells--cells that give rise to a variety of different cell types that have specific functions, such as the immune cells called monocytes.

After the St. Jude team infused the genetically modified BMCs into the laboratory model, resulting monocytes migrated to the degenerating brain cells that lacked the gene for beta-galactosidase. These cells took in the enzyme released by the monocytes and used it to break down excess GM1, thus correcting the potentially fatal buildup of this molecule.

The monocytes homed in on the brain by following a trail of signaling molecules that were released by cells adjacent to the degenerating neurons, according to Alessandra d'Azzo, Ph.D., a member of the St. Jude department of Genetics and Tumor Cell Biology. Such signaling proteins are called chemokines. Under a disease condition, these brain cells, called astrocytes and microglia, release chemokines
'"/>

Contact: Kelly Perry
kelly.perry@stjude.org
901-495-3306
St. Jude Children's Research Hospital
22-Jun-2005


Page: 1 2 3

Related medicine news :

1. Genetically modified cells attack tumors
2. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
3. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
4. New algorithm matches any tumor cells to best possible anti-cancer treatments
5. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
6. Loss of stem cells correlates with premature aging in animal study
7. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
8. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
9. Stanford researchers track human stem cells transplanted into rat brain
10. Nurse cells make life and death decisions for infection-fighting cells
11. Adult brain cells rediscover their inner child

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... December 02, 2016 , ... Yisrayl Hawkins, at The House ... this current generation fits into Bible Prophecy. Yisrayl says this generation, known as the ... this conclusion, showing how the details line up exactly with Bible Prophecy – a ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... to needy individuals and families from eight different sites throughout Miami-Dade and Broward ... Over 1,000 volunteers worked very hard on Thanksgiving morning by putting together individual ...
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for ... $1,000 each from the National Family Partnership and the Drug Enforcement Administration as part ... their homes and the 10 winning schools who decorated their campuses with this year’s ...
(Date:11/30/2016)... ... November 30, 2016 , ... "I hate when the ... while brushing my teeth," said an inventor from Bridgewater, N.J. "I thought that there ... this handy device." , He developed the patent-pending DEFLECTOR to prevent saliva and toothpaste ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For Discovery, ... the opening of a new residential mental health treatment program in Chino Hills, ... such as severe anxiety, depression, bi-polar disorder, and other related issues. , Center ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016 On Thursday, December ... excellence in research, development and innovation in the biopharmaceutical ... was held in the presence of Sergey Tsyb, Vice ... Russian Federation , Natalia Sanina, First Vice Chairman ... , Head of Roszdravnadzor, National Service of Control in ...
(Date:12/2/2016)... RICHMOND, British Columbia , December 2, 2016 ... Produkt, den INSTI HIV-Selbsttest, bei den Mitgliedern des Apothekenbundes von Kenia eingeführt. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) ...
(Date:12/2/2016)... 2016 Lianluo Smart Limited (Nasdaq: ... which develops, markets and sells medical devices and ... and international markets, recently attended the ... New Progress Forum, co-hosted by the Institute of ... , Guangdong Provincial People,s Hospital and Cardiology Department ...
Breaking Medicine Technology:
Cached News: