HOME >> MEDICINE >> NEWS
Genomic tests improve prediction of breast cancer response to chemotherapy, hormonal therapy

SAN ANTONIO -- Researchers at The University of Texas M. D. Anderson Cancer Center have developed two genomic tests to better predict how breast cancer patients will respond to chemotherapy or hormonal therapy.

In presentations Dec. 14-15 at the San Antonio Breast Cancer Symposium, the research team reports on a highly sensitive multiple-gene test designed to predict response to chemotherapy, performed before surgery at M.D. Anderson, and a genomic index that gauges 10-year survival for patients who receive post-operative hormonal therapy with the drug tamoxifen.

"We are moving these tests toward clinical trials, where we can measure improvements in treatment response and track how physicians and patients use this information to make better decisions about treatment," says one of the team leaders, Lajos Pusztai, M.D., Ph.D., associate professor in M. D. Anderson's Department of Breast Medical Oncology.

The team developed a multi-gene predictor for pathological complete response (absence of cancer after chemotherapy), by analyzing 82 women who received preoperative paclitaxel and fluorouracil-doxocrubicin-cyclophsophamide (T/FAC), the standard of care for chemotherapy. Pusztai says the team analyzed 780 different combinations before winnowing the test down to a small set of genes.

The test was then applied to 51 new patients who received identical T/FAC treatment. It accurately predicted 12 of 13 patients who achieved a complete response. Of the 28 patients the test predicted would have residual cancer, 27 had breast cancer after treatment, indicating a high negative predictive value. "That's important, because if you knew in advance that you were unlikely to benefit from this standard chemotherapy, then you might choose a different treatment or an investigational drug," Pusztai says.

The test also predicted that 23 patients would achieve complete response, when only 12 did, mainly because the remainder had
'"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
14-Dec-2006


Page: 1 2 3

Related medicine news :

1. National Academies advisory: Genomics Revolution Conference summary
2. Genomics researchers discover protein deficit that causes drug toxicity
3. Holograms make for better vision tests
4. Study tests oral insulin to prevent type 1 diabetes
5. Diagnostic tests for malaria underused in Zambia
6. UW study tests topical honey as a treatment for diabetic ulcers
7. Experimental flu vaccine appears promising in early tests
8. Light-based probe sees early cancers in first tests on human tissue
9. Study tests oral insulin to prevent type 1 diabetes
10. Rapid flu tests may reduce threat of antibiotic resistance
11. Prompting men to have syphilis tests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Agile Software Development, has been awarded a contract by the Center for Medicare ... (BPA) aims to accelerate the enterprise use of Agile methodologies in a consistent ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards luncheon ... editorial and design excellence across a range of sectors. This year’s program included the ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology:
Cached News: