HOME >> MEDICINE >> NEWS
Giving children access to drug clinical trials is crucial, clofarabine approval shows

The accelerated approval of the drug clofarabine to treat relapsed or refractory pediatric acute lymphoblastic leukemia (ALL) demonstrates the importance of offering children rapid access to new treatments through clinical trials, according to investigators at St. Jude Children's Research Hospital. Refractory or relapsed ALL is a disease that resists treatment.

Clofarabine was approved for use in the treatment of pediatric patients 1 to 21 years old who have relapsed or refractory ALL that developed after at least two regimens of treatment. Researchers say it has been years since a new anti-cancer drug has received U.S. Food and Drug Administration (FDA) approval for pediatric use before approval for adult use. Most new anti-leukemic drugs were developed for use in adults and only later adapted for the treatment of children, they noted in an article on clofarabine published in the May issue of Nature Reviews/Drug Discovery.

"The addition of clofarabine to the list of drugs approved for treating pediatric ALL is especially significant because it has shown significant activity in different types of leukemias that were no longer responding to standard therapy," said Sima Jeha, MD, director of Developmental Therapeutics for Leukemia and Lymphoma at St. Jude and the lead investigator on the pediatric clofarabine trials. "The lack of overlapping toxicities with current agents warrants adding clofarabine to chemotherapy combinations with the aim of achieving even better responses."

During the past few decades, researchers have made major progress in understanding both the biology of leukemias such as ALL and how the genetic makeup of patients affects the outcome of drug therapy. Parallel with these advances, the cure rate for childhood ALL reached 80 percent. Part of this success is due to the modification of therapy for individual patients based on their risk of treatment failure. However, the most significant contribution to the higher survival
'"/>

Contact: Carrie Strehlau
Carrie.Strehlau@stjude.org
901-495-3306
St. Jude Children's Research Hospital
2-May-2005


Page: 1 2 3

Related medicine news :

1. Giving hope back to disabled veterans
2. Giving African surgeons online health information; cancer in minority groups
3. Giving oxygen may do more harm than good, new report shows
4. Chinese children with hearing devices benefit from new speech test
5. Seat belt injuries could signal more serious trauma in children
6. Diet foods for children may lead to obesity
7. Parents depression can weigh on children
8. Study reveals gaps in vaccine financing for underinsured children
9. Young childrens taste preferences may be influenced by fast-food branding
10. Statin drugs may delay progressive artery damage in children
11. First of its kind report on how children with brain tumors perform at school

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
(Date:8/28/2020)... ... August 28, 2020 , ... A July ... that obese individuals are at an increased risk of developing severe COVID-19 symptoms. ... catch COVID-19; however, because the same organ systems that the coronavirus attacks are ...
(Date:8/27/2020)... , ... August 27, 2020 , ... ... Sikara Medspa is a leading aesthetic and wellness retreat. The practice is centered ... surrounding areas of Las Vegas. , Designed to be a sanctuary for ...
(Date:8/26/2020)... ... 26, 2020 , ... Smile Brands Inc. CEO, Steven C. ... leading a session entitled, “A CEO Guide for Delivering and Measuring Inclusion Success”. ... bring together the world’s leading diversity and inclusion executives, HR consultants, and D&I ...
(Date:8/26/2020)... ... ... In “ U.S. Health Insurance Coverage in 2020: A Looming Crisis in Affordability ... about their healthcare coverage. The survey interviewed 4,272 adults over a period of several ... more than two months into the outbreak and subsequent economic displacement. , Analysis ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... , ... August 28, 2020 , ... ... of primary care medical centers in Florida and San Antonio is happy to ... South Texas medical centers. , In this capacity he will serve as community ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... and aesthetic beauty, bringing a unique perspective and approach. Armed with her qualifications ... ventured out to share her knowledge of the human body with the nation ...
(Date:8/27/2020)... ... August 27, 2020 , ... Austin Oral Surgery – an oral ... announce Dr. David Szalay, DDS, MD, has joined the practice. An accomplished oral and ... Pflugerville office, which is scheduled to open this fall. The new office is slated ...
Breaking Medicine Technology:
Cached News: