HOME >> MEDICINE >> NEWS
Glucosamine-like supplement inhibits multiple sclerosis, type 1 diabetes

Irvine, Calif., May 14, 2007 A glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type-1 diabetes mellitus, according to University of California, Irvine health sciences researchers.

In studies on mice, Dr. Michael Demetriou and colleagues with the UC Irvine Center for Immunology found that N-acetylglucosamine (GlcNAc), which is similar but more effective than the widely available glucosamine, inhibited the growth and function of abnormal T-cells that incorrectly direct the immune system to attack specific tissues in the body, such as brain myelin in MS and insulin-producing cells of the pancreas in diabetes. Study results appear on the online version of the Journal of Biological Chemistry.

This finding shows the potential of using a dietary supplement to help treat autoimmune diseases, said Demetriou, an assistant professor of neurology, and microbiology and molecular genetics. Most importantly, we understand how this sugar-based supplement inhibits the cells that attack the body, making metabolic therapy a rational approach to prevent or treat these debilitating diseases.

The UC Irvine study defines how metabolic therapy with the sugar GlcNAc and other related nutrients modifies the growth and autoimmune activitiy of T-cells. Virtually all proteins on the surface of cells, including T-cells, are modified with complex sugars of variable lengths and composition. Recent studies have shown that changes in these sugars are often associated with T-cell hyperactivity and autoimmune disease.

In mouse models of both MS and type 1 diabetes, Demetriou and colleages found that GlcNAc prevented this hyperactivity and autoimmune response by increasing sugar modifications to the T-cell proteins. This therapy normalized T-cell function and prevented development of paralysis in MS and high blood glucose levels in type 1 diabetes.

This study comes o
'"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
14-May-2007


Page: 1 2

Related medicine news :

1. Sucampo Pharmaceuticals submits supplemental new drug application for Lubiprostone to treat IBS-C
2. Folic acid supplements do not appear to reduce risk of colorectal tumors
3. Folic acid supplementation lowers stroke risk
4. Different type of iron supplement is better at boosting iron levels
5. Some vitamin supplements dont protect against lung cancer
6. Vitamin D supplements may offer cheap and effective immune system boost against TB
7. Calcium plus vitamin D supplements may help prevent weight gain in postmenopausal women
8. Cancer-fighting foods, supplements explored in day-long symposium, March 25
9. Energy supplement under study for Parkinsons disease
10. Selenium supplements may contribute to reduced HIV viral load
11. Antenatal fish oil supplements boost kids hand-eye coordination

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... PLEASANTON, Calif. (PRWEB) , ... July 10, 2020 ... ... (NYSE:TFX) focused on addressing unmet needs in the field of urology, today announced ... been designated as a UroLift® Center of Excellence. The designation recognizes that Dr. ...
(Date:7/10/2020)... , ... July 10, 2020 , ... ... 3.0 featuring our Business Partner Vetting (BPV) Portal . Expresso® 3.0 ... upload requested documents. No more manually mailing, tracking, and performing other administrative tasks ...
(Date:7/7/2020)... (PRWEB) , ... July 07, 2020 , ... Dr. ... clients a new way to improve their scalp health. It is now possible to ... adding this treatment process to his practice, Dr. DeJoseph is able to provide clients ...
(Date:7/7/2020)... ... 2020 , ... The Germ-Foggerâ„¢ disinfecting spray system with vortecularâ„¢ ... surfaces is now available in Mexico and Latin America. A new Spanish-language website, ... In this era of worldwide pandemic, the ability to rapidly and efficiently disinfect ...
(Date:7/4/2020)... ... 2020 , ... Houston Life coach, Rashad Garrett, has thrown a lifeline to ... of his new app, Faith Of A Mustard Seed (FOAMS). , The global pandemic ... issues. In fact, a Federal Agency emergency helpline dedicated to helping people in emotional ...
Breaking Medicine News(10 mins):
(Date:7/2/2020)... ... July 02, 2020 , ... Realty ONE Group International, one ... on its live agent Town Halls, furthering its commitment to its real estate ... special guests and Realty ONE Group leadership discussing social, mental, physical and financial ...
(Date:7/1/2020)... , ... July 01, 2020 , ... ... therapy (PDT) for treating cancer, today announced the formation of its Scientific Advisory ... will provide critical medical, scientific, and strategic advice to support company development and ...
(Date:6/28/2020)... ... June 27, 2020 , ... CPAP Store USA, known for its one of ... devices, is growing and expanding at a rapid rate. Today, CPAP store USA is ... CPAP Store Dallas, located at 3920 Rosemeade Parkway, Suite 150, Dallas, Texas 75287. , ...
Breaking Medicine Technology:
Cached News: